robotic surgery

机器人手术
  • 文章类型: Journal Article
    据报道,机器人辅助全膝关节置换术(RATKA)可增强手术决策。这项研究的目的是评估骨切割的预测准确性,下肢对齐,以及术前和术中用于RATKA的新型系统的组件尺寸。
    术前计划的骨切割,肢体对齐,和组件尺寸是使用重建的3D模型投影的。测量术中骨切割和术后肢体对齐。计划和真正的骨头切割之间的错误,肢体对齐,和组件尺寸进行了比较。
    骨切割和对准的平均绝对误差在1.40mm/1.30°内,标准偏差(SD)为0.96mm/1.12°。对于与计划相比的所有骨切割和对齐错误,除股骨远端外侧切口外,差异无统计学意义(P=0.004)。预测股骨的准确性,胫骨,和聚乙烯组件尺寸为100%(48/48),90%(43/48),88%(42/48),分别。关于骨切割和对齐的所有平均绝对误差,在外科医生之间没有观察到显著差异.
    用于RATKA的新颖的机器人辅助系统基于预测准确性提供了可靠的手术决策,而与外科医生的经验水平无关。
    UNASSIGNED: Robotic-assisted total knee arthroplasty (RATKA) has been reported to enhance operative decision-making. The purpose of this study was intended to assess the predictive accuracy of bone cuts, lower limb alignment, and component size of a novel system for RATKA preoperatively and intraoperatively.
    UNASSIGNED: Preoperatively planned bone cuts, limb alignment, and component size were projected using a reconstructed 3D model. Intraoperative bone cuts and postoperative limb alignment were measured. Errors between planned and real bone cuts, limb alignment, and component size were compared.
    UNASSIGNED: The mean absolute errors for bone cuts and alignment were within 1.40mm/1.30° with a standard deviation (SD) of 0.96mm/1.12°. For all errors of bone cuts and alignment compared with the plan, there were no statistically significant differences except for the lateral distal of femoral cuts (P=0.004). The accuracy for predicting the femoral, tibial, and polyethylene component sizes was 100% (48/48), 90% (43/48), and 88% (42/48), respectively. Regarding all mean absolute errors of bone cuts and alignments, no significant differences were observed among surgeons.
    UNASSIGNED: The novel robotically-assisted system for RATKA donated reliable operative decision-making based on the predictive accuracy regardless of the surgeon\'s level of experience.
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  • 文章类型: Journal Article
    机器人手术已越来越多地应用于各种手术领域,但该技术的成本效益仍存在争议,因为其成本较高,且临床结局改善有限.本研究旨在探讨机器人胰腺手术的健康经济意义。调查其对住院费用和各种医疗资源消耗的影响。收集在我们机构接受胰腺手术的患者的数据,并将其分为机器人组和传统组。住院费用的统计分析,逗留时间,不同服务类别的成本,和基于年龄的分组成本分析,BMI类,和接受的程序使用t检验和线性回归进行。尽管机器人组的总住院费用明显高于传统组,医疗耗材的成本显着降低。减少在老年患者中更为突出,肥胖患者,那些接受胰十二指肠切除术的人,这可以归因于机器人手术平台的技术优势,在很大程度上促进了血液控制,组织保护,和缝合。研究得出的结论是,尽管总体成本较高,机器人胰腺手术节省了大量医疗耗材,特别有利于某些患者亚组。这些发现为机器人手术的经济可行性提供了有价值的见解,从卫生经济学的角度支持它的采用。
    Robotic surgery has been increasingly adopted in various surgical fields, but the cost-effectiveness of this technology remains controversial due to its high cost and limited improvements in clinical outcomes. This study aims to explore the health economic implications of robotic pancreatic surgery, to investigate its impact on hospitalization costs and consumption of various medical resources. Data of patients who underwent pancreatic surgery at our institution were collected and divided into robotic and traditional groups. Statistical analyses of hospitalization costs, length of stay, costs across different service categories, and subgroup cost analyses based on age, BMI class, and procedure received were performed using t tests and linear regression. Although the total hospitalization cost for the robotic group was significantly higher than that for the traditional group, there was a notable reduction in the cost of medical consumables. The reduction was more prominent among elderly patients, obese patients, and those undergoing pancreaticoduodenectomy, which could be attributed to the technological advantages of the robotic surgery platform that largely facilitate blood control, tissue protection, and suturing. The study concluded that despite higher overall costs, robotic pancreatic surgery offers significant savings in medical consumables, particularly benefiting certain patient subgroups. The findings provide valuable insights into the economic viability of robotic surgery, supporting its adoption from a health economics perspective.
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  • 文章类型: Journal Article
    目的:手术Apgar评分量化了三个术中参数:最低心率,最低平均动脉压,估计失血量(EBL)。该评分系统基于这些测量的因素来预测术后并发症。本研究旨在探讨改良手术Apgar评分(mSAS)对机器人手术治疗直肠癌患者术后并发症的预测价值,以提高直肠癌患者的生存率和生活质量。
    方法:研究对象为2015年1月至2023年12月在南昌大学第一附属医院胃肠外科接受机器人手术的直肠癌患者。在微创手术中,我们开发了一种为机器人直肠癌手术量身定制的改良手术Apgar评分(mSAS),纳入EBL的调整阈值。该阈值来自524名患者队列的四分位数分析,EBL中位数为100mL(IQR80-130mL)。我们分析了术后并发症与低mSAS的相关性。
    结果:这项研究包括524名患者,其中91例(17.4%)出现并发症,22例(4.2%)出现严重并发症.mSAS为6提供了最大的Youden指数,并确定为临界值。使用mSAS预测并发症的ROC曲线下面积为0.740。单变量和多变量分析表明,年龄较大,较低的肿瘤定位,更长的操作时间,单纯放疗,联合放化疗,和较低的mSAS是并发症的独立危险因素。预测列线图的AUC为0.834(95%CI0.774-0.867)。校准曲线与列线图表现出极好的一致性,指示对角线井的预测曲线。
    结论:这项研究表明,mSAS可能是机器人直肠癌手术后并发症的一个有价值的预测指标,具有潜在的更高的临床效用。
    OBJECTIVE: The Surgical Apgar Score quantifies three intraoperative parameters: lowest heart rate, lowest mean arterial pressure, and estimated blood loss (EBL). This scoring system predicts postoperative complications based on these measured factors. The aim of this study was to investigate the value of modified Surgical Apgar Score (mSAS) in predicting postoperative complications in patients with rectal cancer treated with robotic surgery in order to improve the survival and quality of life of rectal cancer patients.
    METHODS: The study included patients with rectal cancer who underwent robotic surgery in the Department of Gastrointestinal Surgery at the First Affiliated Hospital of Nanchang University from January 2015 to December 2023. In minimally invasive surgery, we developed a modified Surgical Apgar Score (mSAS) tailored for robotic rectal cancer surgery, incorporating an adjusted threshold for EBL. This threshold was derived from quartile analysis of a cohort of 524 patients, with a median EBL of 100 mL (IQR 80-130 mL). We analyzed the association of postoperative complications with low mSAS.
    RESULTS: This study included 524 patients, of which 91 (17.4%) experienced complications and 22 (4.2%) suffered severe complications. mSAS of 6 provided maximal Youden index and were determined as the cut-off values. The area under the ROC curve for predicting complications using the mSAS was 0.740. Univariate and multivariate analyses indicated that an older age, lower tumor localization, longer operation time, radiotherapy alone, combined chemoradiotherapy, and lower mSAS as independent risk factors for complications. The AUC of the prediction nomogram was 0.834 (95% CI 0.774-0.867). The calibration curve demonstrated excellent concordance with the nomogram, indicating the prediction curve ft the diagonal well.
    CONCLUSIONS: This study suggests that mSAS might be a valuable predictive indicator for postoperative complications following robotic rectal cancer surgery, with potentially higher clinical utility.
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  • 文章类型: Journal Article
    达芬奇手术系统(DVS)具有侵入最小的优点,快速恢复,安全,和可靠性。虽然DVS已经广泛应用于各种腹部手术,其在机器人辅助腹膜后肿瘤切除术(RRTR)中的应用描述仅限于病例报告;缺乏大样本系统研究.本研究是为了分析我们中心的RRTR数据,总结我们的经验,为其他腹膜后肿瘤中心提供参考。
    我们回顾性分析了2015年1月至2022年12月在青岛大学附属医院接受RRTR的105例患者的临床资料。进行Logistic单因素和多因素分析以确定影响RRTR的独立危险因素。使用接收器工作特性曲线来找到截止值,然后将其纳入逻辑多变量分析以进行验证。
    在105名患者中,87例顺遂行RRTR(DVS组),18例中转开放手术(中转组)。性别没有显著差异,年龄,身体质量指数,腹部手术史,或肿瘤位置在两组之间(P>0.05)。肿瘤最大直径[比值比(OR),1.041;95%置信区间(CI),1.015-1.067;P=0.002]和病理性质(OR,8.646;95%CI,2.370~31.544;P=0.001)是中转开腹手术的独立危险因素。进一步分析证实,对于最大直径≤64mm的肿瘤和良性肿瘤,RRTR的成功率更高。根据我们的经验和统计结果,我们认为符合以下标准的腹膜后肿瘤具有较高的DDSS切除成功率:最大肿瘤直径≤64mm,良性肿瘤,肿瘤有相对清晰的边界,对周围组织器官无明显侵犯,不需要联合切除器官.
    RRTR治疗RPT安全有效,临床预后与开腹手术相似。在具有适当手术指征的患者中,RRTR的成功率更高。
    UNASSIGNED: The Da Vinci Surgical System (DVSS) has the advantages of minimal invasion, rapid recovery, safety, and reliability. Although the DVSS has been widely used in various abdominal surgeries, descriptions of its use in robot-assisted retroperitoneal tumor resection (RRTR) are limited to case reports; large-sample systematic studies are lacking. The present study was performed to analyze the data of RRTR in our center, summarize our experience, and provide a reference for other retroperitoneal tumor centers.
    UNASSIGNED: We retrospectively analyzed the clinical data of 105 patients who underwent RRTR at the Affiliated Hospital of Qingdao University from January 2015 to December 2022. Logistic univariate and multivariate analyses were performed to identify independent risk factors affecting RRTR. A receiver operating characteristic curve was used to find the cut-off value, which was then included in the logistic multivariate analysis for verification.
    UNASSIGNED: Among the 105 patients, 87 successfully underwent RRTR (DVSS group) and 18 underwent conversion to open surgery (conversion group). There was no significant difference in sex, age, body mass index, history of abdominal surgery, or tumor location between the two groups (P > 0.05). The maximum tumor diameter [odds ratio (OR), 1.041; 95% confidence interval (CI), 1.015-1.067; P = 0.002] and pathological property (OR, 8.646; 95% CI, 2.370-31.544; P = 0.001) were independent risk factors for conversion to open surgery. Further analysis confirmed that the success rate of RRTR was higher for tumors with a maximum diameter of ≤64 mm and benign tumors. Based on our experience and statistical results, we believe that retroperitoneal tumors that meet the following criteria have a higher success rate of DVSS resection: maximum tumor diameter of ≤64 mm, benign tumors, the tumor has relatively clear boundary, no obvious invasion of surrounding tissues and organs, and no need for combined organ resection.
    UNASSIGNED: RRTR is safe and effective in the treatment of RPT, and the clinical prognosis is similar to that of open surgery. The success rate of RRTR in patients with appropriate surgical indications for this procedure is higher.
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  • 文章类型: Journal Article
    尽管机器人手术对乙状结肠和直肠癌患者的安全性和短期结果是有据可查的,关于机器人结直肠手术的长期生存结局的研究有限.这是一项回顾性研究,包括在2016年8月至2021年9月期间接受腹腔镜或机器人前切除术和腹部手术切除直肠或乙状结肠癌的502例患者。所有患者均诊断为直肠或乙状结肠腺癌。实施倾向得分匹配(PSM)以最小化选择偏差。围手术期结果,并发症发生率,和病理资料进行评价和比较。计算并比较5年总生存率和无病生存率。匹配之前,与腹腔镜组相比,机器人组患者的病理T和N分期较早,并且更有可能接受新辅助放化疗.匹配后,两组的大多数临床病理结果相似,但与腹腔镜组相比,机器人组手术时间更长,开腹手术的转化率更低.匹配临床因素后,机器人组5年DFS率为88.19%,腹腔镜组为82.46%(P=0.122),OS率分别为90.5%和79.5%(P=0.342),没有显着差异。在分层分析中,机器人手术组的患者在以下亚组中的5年DFS率明显较高:TNMI-II期,接受新辅助治疗,原发肿瘤位于直肠。与腹腔镜手术相比,机器人手术治疗乙状结肠和直肠癌的安全性和有效性得到了验证。两组患者的长期预后相当。
    Although the safety and short-term outcomes of robotic surgery for sigmoid colon and rectal cancer patients are well-documented, there is limited research on the long-term survival outcomes of robotic colorectal surgery. This is a retrospective study that includes 502 patients who underwent either laparoscopic or robotic anterior resection and abdominoperineal resection for rectal or sigmoid colon cancer between August 2016 and September 2021. All patients were diagnosed with rectal or sigmoid colon adenocarcinoma. Propensity score matching (PSM) was implemented to minimize selection bias. Perioperative outcomes, complication rates, and pathological data were evaluated and compared. The 5-year overall survival rate and disease-free survival rate were calculated and compared. Before matching, patients in the robotic group had earlier pathological T and N stages and were more likely to have received neoadjuvant chemoradiotherapy compared to the laparoscopic group. After matching, most clinicopathological outcomes were similar between the two groups, but the robotic group had longer operative times and a lower conversion rate to open surgery compared with laparoscopic group. After matching for clinical factors, the 5-year DFS rates were 88.19% for the robotic group and 82.46% for the laparoscopic group (P = 0.122), and the OS rates were 90.5% and 79.5% (P = 0.342), showing no significant differences. In the stratified analysis, patients in the robotic surgery group had significantly higher 5-year DFS rates in the following subgroups: age < 65 years, TNM stage I-II, received neoadjuvant therapy, and primary tumor located in the rectum. The safety and efficacy of robotic surgery for sigmoid colon and rectal cancer were validated compared to laparoscopic surgery, with both groups of patients exhibiting comparable long-term prognoses.
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  • 文章类型: Journal Article
    背景:随着机器人手术系统在手术领域的普及,机器人胃癌手术在我国也得到了充分的应用和推广。中国机器人胃癌手术指南于2021年8月发表在《中国普通外科杂志》上。
    方法:我们对机器人胃癌手术的适应症进行了详细的解释,禁忌症,围手术期准备,手术步骤,并发症,和术后管理基于中国机器人胃癌手术指南的建议,并辅以其他手术指南,共识,单中心体验。
    结果:详细介绍了机器人胃癌围手术期临床管理的20个经验。
    结论:我们希望能给一线临床医生在机器人胃癌手术治疗中带来一定的临床参考价值。
    背景:指南已在国际惯例指南注册平台上注册(http://www.指南-注册表。cn)(注册号:IPGRP-2020CN199)。
    BACKGROUND: With the popularization of robotic surgical systems in the field of surgery, robotic gastric cancer surgery has also been fully applied and promoted in China. The Chinese Guidelines for Robotic Gastric Cancer Surgery was published in the Chinese Journal of General Surgery in August 2021.
    METHODS: We have made a detailed interpretation of the process of robotic gastric cancer surgery regarding the indications, contraindications, perioperative preparation, surgical steps, complication, and postoperative management based on the recommendations of China\'s Guidelines for Robotic Gastric Cancer Surgery and supplemented by other surgical guidelines, consensus, and single-center experience.
    RESULTS: Twenty experiences of perioperative clinical management of robotic gastric cancer surgery were described in detail.
    CONCLUSIONS: We hope to bring some clinical reference values to the front-line clinicians in treating robotic gastric cancer surgery.
    BACKGROUND: The guidelines were registered on the International Practice Guideline Registration Platform ( http://www.guidelines-registry.cn ) (registration number: IPGRP-2020CN199).
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  • 文章类型: Journal Article
    目的:本研究的目的是回顾性比较新生儿机器人(RAD)和腹腔镜辅助十二指肠菱形吻合术(LAD)的短期结局。
    方法:对2019年1月至2022年12月期间接受RAD(n=30)或LAD(n=38)的新生儿进行回顾性分析。收集了主要患者数据,包括术前,术中,和术后信息。
    结果:所有患者均为30日龄以下、体重4kg的新生儿。30例(44.1%)新生儿接受了RAD,38例(55.9%)新生儿接受了LAD。与LAD组相比,RAD组腹内手术时间较短(RAD,60.0(50.0~70.0)min;LAD,79.9(69.0~95.3)min;p<0.001)。两组之间的即时和30天并发症没有显着差异。
    结论:RAD对新生儿安全有效。与传统的LAD相比,RAD显示出可比较的结果。
    OBJECTIVE: The purpose of this study was to retrospectively compare the short-term outcomes of robotic- (RAD) and laparoscopic-assisted duodenal diamond-shaped anastomosis (LAD) in neonates.
    METHODS: Neonates who underwent RAD (n = 30) or LAD (n = 38) between January 2019 and December 2022 were analyzed retrospectively. Major patient data were collected, including preoperative, intraoperative, and postoperative information.
    RESULTS: All patients were neonates below the age of 30 days weighing 4 kg. Thirty (44.1%) neonates underwent RAD and 38 neonates (55.9%) underwent LAD. Compared to the LAD group, the RAD group had a shorter intra-abdominal operation time (RAD, 60.0(50.0 ~ 70.0) min; LAD, 79.9(69.0 ~ 95.3) min; p < 0.001). There were no significant differences in immediate and 30-day complications between the two groups.
    CONCLUSIONS: RAD is safe and effective in neonates. Compared to traditional LAD, RAD showed comparable results.
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  • 文章类型: English Abstract
    UNASSIGNED: To explore the method of preventing heat steam induced skin damage in robotic nipple-sparing mastectomy and immediate breast reconstruction (R-NSM-IBR) using Da Vinci Robots.
    UNASSIGNED: A clinical data of 128 female patients with breast cancer, who were treated with R-NSM-IBR between September 2022 and December 2023 and met the selection criteria, was retrospectively analyzed. During robotic nipple-sparing mastectomy, the breasts were covered with gauze cooled by ice water to reduce skin temperature in 99 cases (group A) and were not treated in 29 cases (group B). There was no significant difference in the age, affected side, body mass index, pathological type of breast cancer, and constituent ratios of adjuvant chemotherapy and neoadjuvant chemotherapy between the two groups ( P>0.05). Intraoperative breast skin temperature, unilateral robotic nipple-sparing mastectomy time, and the incidence of complications of breast heat steam induced skin damage were recorded.
    UNASSIGNED: The time for unilateral robotic nipple-sparing mastectomy was (77.18±9.23) minutes in group A and (76.38±12.88) minutes in group B, with significant difference between the two groups ( P<0.05). The intraoperative breast skin temperature was significantly lower in group A than in group B [(25.61±0.91)℃ vs (33.38±1.14)℃; P<0.05]. Seven cases of heat steam skin damage occurred during operation, including 2 cases (2.0%) in group A and 5 cases (17.2%) in group B, with a significant difference in incidence between the two groups ( P<0.05). Among them, 1 patient in group B had a vesication rupture and infection, which eventually led to the removal of the implant; the rest of the patients were treated with postoperative interventions for skin recovery.
    UNASSIGNED: The use of breast covered with gauze cooled by ice water during R-NSM-IBR can effectively reduce the risk of heat steam induced skin damage.
    UNASSIGNED: 探讨达芬奇机器人保留乳头乳晕乳腺切除即刻假体乳房重建术(robotic nipple-sparing mastectomy and immediate breast reconstruction,R-NSM-IBR)中预防热蒸汽损伤皮肤组织的方法。.
    UNASSIGNED: 回顾性分析2022年9月—2023年12月接受R-NSM-IBR治疗且符合选择标准的128例乳腺癌女性患者临床资料。术中乳腺切除期间,99例采用覆盖冰水冷却后纱布来降低乳房皮肤温度(A组),29例不作处理(B组)。两组患者年龄、手术侧别、身体质量指数、乳腺癌病理类型及接受辅助化疗、新辅助化疗构成比比较,差异均无统计学意义( P>0.05)。记录并比较术中乳房表面温度、单侧乳腺切除时间以及术中乳房热损伤并发症发生情况。.
    UNASSIGNED: A、B组单侧乳腺切除时间分别为(77.18±9.23)、(76.38±12.88)min,差异有统计学意义( P<0.05)。A组术中乳房表面温度为(25.61±0.91)℃,低于B组(33.38±1.14)℃,差异亦有统计学意义( P<0.05)。术中7例发生皮肤热损伤,其中A组2例(2.0%)、B组5例(17.2%),发生率差异有统计学意义( P<0.05)。其中,B组1例水疱破裂并感染,最终导致假体取出;其余患者均干预处理后恢复正常。.
    UNASSIGNED: R-NSM-IBR术中采用在乳房表面覆盖冰水冷却后纱布降温方法可有效降低热蒸汽损伤皮肤的风险。.
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  • 文章类型: Journal Article
    UNASSIGNED: To review the research progress related to endoscopic surgery and robotic surgery for breast diseases, aiming to provide references for clinical practice.
    UNASSIGNED: The recent domestic and international literature on endoscopic surgery and robotic surgery for breast diseases was reviewed, then the challenges in their development, the innovative evolution of endoscopic surgery combined with clinical practice by our team, and its clinical applications were summarized.
    UNASSIGNED: Traditional endoscopic surgery, despite its advantages such as minimal invasiveness, good cosmetic outcomes, and high patient\'s satisfaction, has been limited in its development due to specific difficulties in establishing the operative field. Our team innovatively proposed the \"reverse sequence method\" and the Huaxi Hole 1 theory and methods, cleverly altering the surgical procedure sequence, adding small operative orifices to transform single-port operations into multi-port ones, effectively overcoming the challenges restricting the advancement of endoscopic surgery in the field of breast diseases, thereby enabling further proliferation of endoscopic procedures. In terms of breast endoscopic reconstruction surgery, the parachute patch technique has broadened the indications for reconstruction surgery, benefiting patients with a certain degree of breast ptosis; and the postoperative adjustment concept, through early intervention in the post-reconstruction breast shape, has further refined the reconstruction procedure. Robot-assisted surgery derived from endoscopic surgery theory has further enhanced the precision and stability of surgeries, reducing surgical risks; however, excessive time and economic costs are urgent issues that must be addressed.
    UNASSIGNED: Through theoretical innovations, endoscopic surgery has been applied in the excision and reconstruction of breast lesions, while robotic surgery shows promising applications in autologous breast reconstruction, especially in the latissimus dorsi reconstruction field. Nevertheless, the lack of high-level large-sample, multi-center randomized controlled clinical trials to confirm its surgical safety, oncological safety, and postoperative cosmetic outcomes is an important direction for future research.
    UNASSIGNED: 对针对乳腺疾病开展的腔镜和机器人手术相关研究进展进行综述,为临床提供参考。.
    UNASSIGNED: 查阅近年来国内外乳腺疾病腔镜与机器人手术相关研究文献,从其发生发展的困境、本团队结合临床实践对腔镜手术的创新性演变及其临床应用等方面进行总结分析。.
    UNASSIGNED: 传统腔镜手术尽管具备创伤小、美容学效果好、患者满意度高等优点,但由于建腔存在一定困难,限制了其发展。本团队创新性提出“逆序法”、辅助孔等理论与方法,通过改变手术操作顺序、增加微小辅助孔将单孔操作变成多孔操作等技巧,解决了制约腔镜手术在乳腺疾病领域进展的困难,有利于腔镜手术普及并推广。在乳腺腔镜假体重建手术方面,降落伞补片法拓宽了其适应证,使乳房具备一定下垂度患者也能获益;而术后调整思想通过对重建术后乳房外形的早期干预,进一步完善了重建手术的美容学效果。源于腔镜手术理论的机器人手术进一步提升了手术精准度和稳定性,降低了学习难度,然而时间成本和经济成本过度消耗是当前需要解决的问题。.
    UNASSIGNED: 经过理论创新,腔镜手术已普遍适用于乳腺疾病领域的肿物切除和全乳切除后重建,沿用其理论的机器人手术在乳房重建方面可以进一步降低学习难度,但目前仍缺少高水平大样本、多中心的随机对照临床试验验证腔镜及机器人乳腺手术的外科学安全性、肿瘤学安全性以及术后美容学效果,这也是后续研究的重要方向。.
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  • 文章类型: Journal Article
    背景:肿瘤患者常发生术后谵妄(POD),进一步加重了医疗和经济负担。下腹部肿瘤切除术中的机器人技术减少了手术创伤,但增加了二氧化碳(CO2)吸收等风险。本研究旨在调查不同潮气末CO2水平下POD发生的差异。
    方法:本研究经河北大学附属医院伦理委员会批准(HDFY-LL-2022-169)。该研究在中国临床试验注册中心注册,网址为:http://www。chictr.org.cn,登记号:ChiCTR2200056019(登记日期:2022年8月27日)。在2022年9月1日至2022年12月31日计划进行机器人下腹部肿瘤切除术的患者中,术后三天使用带有临床回顾记录的CAM量表进行全面的谵妄评估。根据插管后的随机分组,术中给予不同的etCO2。L组接受了较低水平的二氧化碳管理(31-40mmHg),H组在气腹期间维持较高水平(41-50mmHg)。使用Pearson卡方或Wilcoxon秩和检验和多元逻辑回归分析数据。术前精神状态评分,酒精损伤评分,尼古丁依赖评分,高血压和糖尿病史,手术时间和最差疼痛评分与基本患者信息一起纳入回归模型,用于协变量校正分析.
    结果:在103名患者中,19人(18.4%)发生术后谵妄。不同ETCO2组谵妄发生率L组为21.6%,H组为15.4%,分别,没有统计学差异。在调整后的多变量分析中,年龄和手术期间是术后谵妄的统计学显著预测因素.屏气试验在术后显著降低,但两组间无统计学差异。
    结论:使用机器人助手,不同的呼气末二氧化碳管理不能改善下腹部肿瘤切除术患者术后谵妄的发生率,然而,年龄和手术时间是正相关的危险因素.
    BACKGROUND: Postoperative delirium (POD) often occurs in oncology patients, further increasing the medical and financial burden. Robotic technology in lower abdominal tumors resection reduces surgical trauma but increases risks such as carbon dioxide (CO2) absorption. This study aimed to investigate the differences in their occurrence of POD at different end-tidal CO2 levels.
    METHODS: This study was approved by the Ethics Committee of Affiliated Hospital of He Bei University (HDFY-LL-2022-169). The study was registered with the Chinese Clinical Trials Registry on URL: http://www.chictr.org.cn , Registry Number: ChiCTR2200056019 (Registry Date: 27/08/2022). In patients scheduled robotic lower abdominal tumor resection from September 1, 2022 to December 31, 2022, a comprehensive delirium assessment was performed three days postoperatively using the CAM scale with clinical review records. Intraoperative administration of different etCO2 was performed depending on the randomized grouping after intubation. Group L received lower level etCO2 management (31-40mmHg), and Group H maintained the higher level(41-50mmHg) during pneumoperitoneum. Data were analyzed using Pearson Chi-Square or Wilcoxon Rank Sum tests and multiple logistic regression. Preoperative mental status score, alcohol impairment score, nicotine dependence score, history of hypertension and diabetes, duration of surgery and worst pain score were included in the regression model along with basic patient information for covariate correction analysis.
    RESULTS: Among the 103 enrolled patients, 19 (18.4%) developed postoperative delirium. The incidence of delirium in different etCO2 groups was 21.6% in Group L and 15.4% in Group H, respectively, with no statistical differences. In adjusted multivariate analysis, age and during of surgery were statistically significant predictors of postoperative delirium. The breath-hold test was significantly lower postoperatively, but no statistical differences were found between two groups.
    CONCLUSIONS: With robotic assistant, the incidence of postoperative delirium in patients undergoing lower abdominal tumor resection was not modified by different end-tidal carbon dioxide management, however, age and duration of surgery were positively associated risk factors.
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