背景:慢性阻塞性肺疾病(COPD)的发生与氧化应激有关。氧化平衡评分(OBS)可以评价机体的氧化和抗氧化状况。然而,我们没有发现研究这两者之间的关联.
目的:评估OBS与COPD患病率之间的关系,并探讨旨在预防和延缓成人COPD的饮食和生活方式。
方法:我们使用NHANES的数据纳入了13,909名参与者。采用加权logistic回归模型和加权约束三次样条曲线探讨OBS与COPD的关系。采用亚组分析和敏感性分析确定结果的稳定性。中介分析用于评估炎症因子的作用。
结果:在逻辑回归模型中,与OBS的最低四分位数相比,OBS的最高四分位数,饮食OBS,生活方式OBS和COPD有奇数比率OR(95CI)=0.67(0.51,0.89),OR(95%CI)=0.71(0.55,0.93),OR(95%CI)分别为0.39(0.26,0.58)。受限三次样条曲线显示,OBS和膳食OBS与COPD患病率呈L形曲线,而生活方式OBS与COPD患病率呈负相关曲线。亚组分析和敏感性分析证明了关联的稳健性。中介分析显示炎症因子介导OBS与COPD患病率的关系。
结论:OBS的增加,膳食OBS,和生活方式OBS与COPD患病率下降相关,但过度OBS和饮食OBS与COPD风险的降低甚至增加相关.
BACKGROUND: The occurrence of chronic obstructive pulmonary disease (COPD) is associated with oxidative stress. Oxidation Balance Score (OBS) can evaluate the oxidation and antioxidant status of the body. However, we found no studies that examined the association between the two.
OBJECTIVE: To assess the association between OBS and COPD prevalence, and to explore dietary and lifestyle patterns aimed at preventing and delay COPD in adults.
METHODS: We included 13,909 participants using data from the NHANES. Weighted logistic regression model and weighted restricted cubic spline curve were used to explore the relationship between OBS and COPD. Subgroup analysis and sensitivity analysis were used to determine the stability of results. Mediation analysis was employed to assess the effect of inflammatory factors.
RESULTS: In logistic regression model, compared with the lowest quartile of OBS, the highest quartile of OBS, diet OBS, lifestyle OBS and COPD had odd ratios OR(95%CI)=0.67 (0.51, 0.89), OR (95% CI) = 0.71 (0.55, 0.93), and OR (95% CI) = 0.39 (0.26, 0.58) respectively. The restricted cubic spline curve reveals that OBS and dietary OBS exhibit an L-shaped curve in relation to COPD prevalence, while lifestyle OBS shows a negative correlation curve with COPD prevalence. Subgroup analysis and sensitivity analysis proved the robustness of the association. Mediation analysis demonstrated that inflammatory factors mediate the association of OBS on the prevalence of COPD.
CONCLUSIONS: The increase of OBS, dietary OBS, and lifestyle OBS was associated with a decrease in the prevalence of COPD, but excessive OBS and dietary OBS were associated with an inapparent decrease or even increased risk of COPD.