未经评估:许多观察性研究表明,肥胖强烈影响皮肤和软组织感染(STTI)。然而,肥胖与SSTI之间是否存在遗传因果关系尚不清楚.
UNASSIGNED:一项双样本孟德尔随机化(MR)研究使用公开发布的全基因组关联研究(GWAS)来探讨肥胖是否与SSTI有因果关系。采用逆方差加权(IVW)分析作为主要分析,结果报告为比值比(ORs)。使用CochranQ检验和I2统计量检验了异质性,使用MR-Egger截距和MR多效性残差和异常值(MR-PRESSO)测试水平多效性。
未经评估:MR分析结果显示BMI对STTI有积极影响(OR1.544,95%CI1.399-1.704,P=5.86×10-18)。在调整2型糖尿病(T2D)和外周血管疾病(PVD)的影响后,积极作用仍然存在。然后,我们进一步评估了BMI对不同类型SSTI的影响.结果显示,BMI导致脓疱病的风险增加,皮肤脓肿,furb和carb,蜂窝织炎,成毛囊肿,以及其他皮肤和皮下组织的局部感染,除了急性淋巴结炎.然而,在调整T2D和PVD的影响后,关联消失了,BMI与脓疱疮或蜂窝织炎之间的关联消失。最后,我们评估了几种肥胖相关特征对STTI的影响.腰围,臀围,身体脂肪百分比,和全身脂肪,不包括腰臀比,对SSTI风险增加有因果关系。然而,在调整BMI的影响后,这种关联消失了.
UNASSIGNED:这项研究发现,肥胖对SSTI有积极的因果效应。合理控制体重是减少SSTI发生的可能途径,尤其是在接受手术的患者中。
Many observational studies have shown that obesity strongly affects skin and soft tissue infections (SSTIs). However, whether a causal genetic relationship exists between obesity and SSTIs is unclear.
A two-sample Mendelian randomization (MR) study was used to explore whether obesity is causally associated with SSTIs using a publicly released genome-wide association study (GWAS). An inverse-variance weighted (IVW) analysis was used as the primary analysis, and the results are reported as the odds ratios (ORs). Heterogeneity was tested using Cochran\'s Q test and the I2 statistic, and horizontal pleiotropy was tested using the MR-Egger intercept and MR pleiotropy residual sum and outlier (MR-PRESSO).
The results of the MR analysis showed a positive effect of BMI on SSTIs (OR 1.544, 95% CI 1.399-1.704, P= 5.86 × 10-18). After adjusting for the effect of type 2 diabetes (T2D) and peripheral vascular disease (PVD), the positive effect still existed. Then, we further assessed the effect of BMI on different types of SSTIs. The results showed that BMI caused an increased risk of
impetigo, cutaneous abscess, furuncle and carbuncle, cellulitis, pilonidal cyst, and other local infections of skin and subcutaneous tissues, except for acute lymphadenitis. However, the associations disappeared after adjusting for the effect of T2D and PVD, and the associations between BMI and
impetigo or cellulitis disappeared. Finally, we assessed the effects of several obesity-related characteristics on SSTIs. Waist circumference, hip circumference, body fat percentage, and whole-body fat mass, excluding waist-to-hip ratio, had a causal effect on an increased risk of SSTIs. However, the associations disappeared after adjusting for the effect of BMI.
This study found that obesity had a positive causal effect on SSTIs. Reasonable weight control is a possible way to reduce the occurrence of SSTIs, especially in patients undergoing surgery.