■复发性妊娠丢失(RPL)是育龄妇女的严重创伤事件。然而,RPL与女性性功能障碍之间的关联未知.
■该研究试图调查RPL与性功能障碍之间的关联,探讨RPL患者性功能障碍的危险因素。
■从2021年5月至2023年1月,在中国西部的3家不同医院进行了一项涉及RPL患者和健康女性的多中心横断面研究。收集基线信息,包括社会人口统计学数据和疾病史。女性性功能指数(FSFI)用于评估参与者的性功能。
■主要结果是性功能障碍风险增加的女性比例(FSFI总分<26.55),次要结局是RPL患者性功能障碍的危险因素。
■本研究共纳入233例RPL患者和185例健康女性。RPL患者的总FSFI评分明显较低(中位数31.7[四分位距,26.6-33.5]vs33.0[四分位数间距,31.2-34.1];P<.001),并且性功能障碍的风险明显高于健康女性(24.9%vs8.6%;P<.001)。体重指数>24kg/m2(调整后的比值比[OR],4.132;95%置信区间[CI],1.902-8.976,P<.001),工作>8小时/天(调整或,2.111;95%CI,1.020-4.369,P=0.044),和无法解释的RPL(调整后的OR,3.785;95%CI,1.967-7.280,P<.001)是RPL患者性功能障碍的独立危险因素。
■RPL患者,尤其是那些有上述危险因素的患者,应该关注性功能障碍的风险,可以采取适当的预防措施。
■我们首次探讨了RPL与性功能障碍的关系,并探讨了RPL患者性功能障碍的危险因素,多中心数据增加了结果的泛化性。然而,横断面设计没有提供RPL和性功能障碍之间的确切因果关系,与心理健康相关的潜在危险因素未进行调查.
■RPL患者性功能障碍的风险增加。超重,工作造成的疲劳,原因不明的RPL是RPL患者性功能障碍的危险因素。
UNASSIGNED: Recurrent pregnancy loss (RPL) is a severe traumatic event for women of childbearing age. However, the association between RPL and female sexual dysfunction was unknown.
UNASSIGNED: The study sought to investigate the association between RPL and sexual dysfunction, and to explore the risk factors of sexual dysfunction for RPL patients.
UNASSIGNED: A multicenter cross-sectional study involving both RPL patients and healthy women was performed in 3 different hospitals in West
China from May 2021 to January 2023. Baseline information including sociodemographic data and disease histories were collected. The Female Sexual Function Index (FSFI) was used to assess the sexual function of participants.
UNASSIGNED: The main outcome was the proportion of women at increased risk of sexual dysfunction (total FSFI scores <26.55), and the secondary outcome was risk factors of sexual dysfunction in RPL patients.
UNASSIGNED: A total of 233 RPL patients and 185 healthy women were included in this study. RPL patients had significantly lower total FSFI scores (median 31.7 [interquartile range, 26.6-33.5] vs 33.0 [interquartile range, 31.2-34.1]; P < .001) and a significantly higher risk of sexual dysfunction than healthy women (24.9% vs 8.6%; P < .001). Body mass index >24 kg/m2 (adjusted odds ratio [OR], 4.132; 95% confidence interval [CI], 1.902-8.976, P < .001), working >8 h/d (adjusted OR, 2.111; 95% CI, 1.020-4.369, P = .044), and unexplained RPL (adjusted OR, 3.785; 95% CI, 1.967-7.280, P < .001) were independent risk factors of sexual dysfunction for RPL patients.
UNASSIGNED: RPL patients, especially those patients with the previously mentioned risk factors, should be focused on the risk of sexual dysfunction, and appropriate preventions could be applied.
UNASSIGNED: We explored the association between RPL and sexual dysfunction and explored the risk factors of sexual dysfunction among RPL patients for the first time, and the multicenter data increased the generalizability of results. However, the cross-sectional design did not provide an exact causal relationship between RPL and sexual dysfunction, and potential risk factors related to mental health were not investigated.
UNASSIGNED: RPL patients were at an increased risk of sexual dysfunction. Overweight, fatigue caused by work, and unexplained RPL were risk factors of sexual dysfunction for RPL patients.