PDF(Pubmed)
Abstract：
UNASSIGNED: Atypical antipsychotics (AAPs)-induced sexual dysfunction (SD) is a frequent issue in clinical practice, often underestimated by clinicians and not extensively researched. The current study aimed to quantify the strength of association between the use of different AAPs and SD using real-world data from the FDA Adverse Event Reporting System (FAERS), as well as investigate the receptor mechanisms that are involved.
UNASSIGNED: Data from the FAERS database from the first quarter of 2004 to the third quarter of 2023 were queried through OpenVigil 2.1. Disproportionality analysis was estimated using the reporting odds ratio (ROR) and information component (IC) methods, and linear regression was used to investigate the relationship between ROR and receptor occupancy which was estimated using in vitro receptor binding profiles.
UNASSIGNED: Our analysis yielded 4839 reports that co-mentioned AAP and SD events, and the findings revealed statistical associations between 12 AAPs and SD. The highest signal value was identified for iloperidone reporting retrograde ejaculation with iloperidone (ROR = 832.09, ROR025 = 552.77; IC = 9.58, IC025 = 6.36), followed by compulsive sexual behavior with aripiprazole (ROR = 533.02, ROR025 = 435.90; IC = 7.30, IC025 = 5.97), and psychosexual disorder for aripiprazole (ROR = 145.80, ROR025 = 109.57; IC025 = 6.47, IC025 = 4.86). Different characteristics of the SD side effects in each AAPs were discovered after further data mining. Regression analysis revealed potential effects for receptor occupancy of D2, D3, and 5-HT1A receptors on ROR. However, no significant correlation persisted following sensitivity analyses.
UNASSIGNED: This is the first study to investigate the AAP-SD associations by using FAERS. In this study, we report for the first time a significant association between aripiprazole and SD based on real-world data. The study suggests that different AAPs have varying levels of association with SD, and the D2, D3, and 5-HT1A receptor occupancy may contribute to potential mechanisms. The findings of this study warrant further validation of more studies and clinical causality assessment.
UNASSIGNED: Data from the FAERS database from the first quarter of 2004 to the third quarter of 2023 were queried through OpenVigil 2.1. Disproportionality analysis was estimated using the reporting odds ratio (ROR) and information component (IC) methods, and linear regression was used to investigate the relationship between ROR and receptor occupancy which was estimated using in vitro receptor binding profiles.
UNASSIGNED: Our analysis yielded 4839 reports that co-mentioned AAP and SD events, and the findings revealed statistical associations between 12 AAPs and SD. The highest signal value was identified for iloperidone reporting retrograde ejaculation with iloperidone (ROR = 832.09, ROR025 = 552.77; IC = 9.58, IC025 = 6.36), followed by compulsive sexual behavior with aripiprazole (ROR = 533.02, ROR025 = 435.90; IC = 7.30, IC025 = 5.97), and psychosexual disorder for aripiprazole (ROR = 145.80, ROR025 = 109.57; IC025 = 6.47, IC025 = 4.86). Different characteristics of the SD side effects in each AAPs were discovered after further data mining. Regression analysis revealed potential effects for receptor occupancy of D2, D3, and 5-HT1A receptors on ROR. However, no significant correlation persisted following sensitivity analyses.
UNASSIGNED: This is the first study to investigate the AAP-SD associations by using FAERS. In this study, we report for the first time a significant association between aripiprazole and SD based on real-world data. The study suggests that different AAPs have varying levels of association with SD, and the D2, D3, and 5-HT1A receptor occupancy may contribute to potential mechanisms. The findings of this study warrant further validation of more studies and clinical causality assessment.
摘要：
■非典型抗精神病药（AAP）引起的性功能障碍（SD）是临床实践中的常见问题，经常被临床医生低估，没有广泛研究。当前的研究旨在使用FDA不良事件报告系统（FAERS）的实际数据来量化使用不同AAP和SD之间的关联强度。以及研究所涉及的受体机制。
■FAERS数据库从2004年第一季度到2023年第三季度的数据通过OpenVigil2.1查询。不相称性分析使用报告优势比(ROR)和信息成分(IC)方法进行估计，线性回归用于研究ROR与受体占有率之间的关系，该关系是使用体外受体结合谱估算的。
■我们的分析产生了4839份报告，共同提到了AAP和SD事件，研究结果揭示了12种AAP和SD之间的统计关联。对于报告使用伊潘立酮逆行射精的伊潘立酮，确定了最高信号值（ROR=832.09，ROR025=552.77；IC=9.58，IC025=6.36），其次是阿立哌唑强迫性行为（ROR=533.02，ROR025=435.90；IC=7.30，IC025=5.97），和阿立哌唑的性心理障碍（ROR=145.80，ROR025=109.57；IC025=6.47，IC025=4.86）。经过进一步的数据挖掘，发现了每种AAP中SD副作用的不同特征。回归分析揭示了D2、D3和5-HT1A受体对ROR的受体占有率的潜在影响。然而,敏感性分析后无显著相关性.
■这是第一项使用FAERS调查AAP-SD关联的研究。在这项研究中,我们首次基于真实数据报道了阿立哌唑与SD之间的显著关联.研究表明，不同的AAP与SD的关联程度不同，D2、D3和5-HT1A受体的占有率可能有助于潜在的机制。这项研究的结果值得进一步验证更多的研究和临床因果关系评估。
■FAERS数据库从2004年第一季度到2023年第三季度的数据通过OpenVigil2.1查询。不相称性分析使用报告优势比(ROR)和信息成分(IC)方法进行估计，线性回归用于研究ROR与受体占有率之间的关系，该关系是使用体外受体结合谱估算的。
■我们的分析产生了4839份报告，共同提到了AAP和SD事件，研究结果揭示了12种AAP和SD之间的统计关联。对于报告使用伊潘立酮逆行射精的伊潘立酮，确定了最高信号值（ROR=832.09，ROR025=552.77；IC=9.58，IC025=6.36），其次是阿立哌唑强迫性行为（ROR=533.02，ROR025=435.90；IC=7.30，IC025=5.97），和阿立哌唑的性心理障碍（ROR=145.80，ROR025=109.57；IC025=6.47，IC025=4.86）。经过进一步的数据挖掘，发现了每种AAP中SD副作用的不同特征。回归分析揭示了D2、D3和5-HT1A受体对ROR的受体占有率的潜在影响。然而,敏感性分析后无显著相关性.
■这是第一项使用FAERS调查AAP-SD关联的研究。在这项研究中,我们首次基于真实数据报道了阿立哌唑与SD之间的显著关联.研究表明，不同的AAP与SD的关联程度不同，D2、D3和5-HT1A受体的占有率可能有助于潜在的机制。这项研究的结果值得进一步验证更多的研究和临床因果关系评估。
