PDF(Pubmed)
Abstract：
Oyster peptide (OP) and Pfaffia glomerata extract (PGE) were used as raw materials. The optimal formulation of the pressed candy (PC) was optimized by one-way experiment and D-optimal mixture experiment design, and animal experiment was used to evaluate the effect of PC on male sexual dysfunction. The results showed that PC intervention significantly improved the sexual behavior of male mice with sexual dysfunction, including a significant shortening of the mount latency (ML) and intromission latency, and a significant increase in the mount frequency (MF) and intromission frequency (IF). At the same time, the concentrations of serum testosterone (T) and luteinizing hormone (LH) in mice were restored, and the erectile parameters and pathological changes of penile tissue were improved. Further studies found that PC intervention increased the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) and reduced the content of malondialdehyde (MDA) in testicular tissue. In addition, PC intervention improved testicular tissue morphology. In conclusion, the obtained PC has good taste quality, and the relevant quality indicators are qualified. It has a good ameliorative effect on male sexual dysfunction and may be a potential dietary supplement.
摘要：
以牡蛎肽（OP）和Pfaffiaglomerata提取物（PGE）为原料。通过单向实验和D-最佳混合实验设计，优化了压榨糖果(PC)的最佳配方，动物实验评价PC对男性性功能障碍的影响。结果表明,PC干预显著改善了性功能障碍雄性小鼠的性行为,包括显著缩短安装延迟(ML)和引入延迟，安装频率(MF)和引入频率(IF)显著增加。同时,小鼠血清睾酮(T)和黄体生成素(LH)浓度恢复,勃起参数和阴茎组织病理变化均得到改善。进一步研究发现,PC干预可提高超氧化物歧化酶(SOD)活性,过氧化氢酶(CAT),和谷胱甘肽过氧化物酶（GSH-Px），并降低睾丸组织中丙二醛（MDA）的含量。此外,PC干预改善睾丸组织形态学。总之,获得的PC具有良好的味道质量，相关质量指标合格。它对男性性功能障碍有很好的改善作用，可能是一种潜在的膳食补充剂。
