■由某些病毒和寄生虫引起的持续感染与多种疾病和大量死亡率有关。重金属是普遍存在的具有免疫抑制特性的环境污染物。这项研究旨在确定重金属暴露是否会抑制免疫系统,从而增加对持续性感染的易感性。
■使用NHANES1999-2016年的数据,我们探索了重金属暴露与持续感染之间的关联:巨细胞病毒(CMV),爱泼斯坦-巴尔病毒(EBV)丙型肝炎病毒(HCV),单纯疱疹病毒1型(HSV-1),弓形虫(T.gondii),以及犬弓形虫和弓形虫(弓形虫属。)通过执行逻辑回归,加权分位数和(WQS)和贝叶斯核机回归(BKMR)模型。中介分析用于确定宿主免疫功能在这些关联中的中介作用。
■Logistic回归分析显示,多种重金属与持续感染风险增加之间存在正相关关系。在WQS模型中,重金属混合物与几种持续性感染的风险增加相关:CMV(OR:1.58;95%CI:1.17,2.14),HCV(OR:2.94;95%CI:1.68,5.16),HSV-1(OR:1.25;95%CI:1.11,1.42),T.gondii(OR:1.97;95%CI:1.41,2.76),和弓形虫属。(OR:1.76;95%CI:1.16,2.66)。BKMR模型进一步证实了重金属混合物的联合作用,并确定了砷的单独作用,镉,和铅。关于调解分析,全身免疫炎症指数,这反映了宿主的免疫状态,介导了12.14%的混合重金属暴露与HSV-1感染的关联。
■这项研究的结果表明,重金属暴露可能会增加对持续性感染的敏感性,与宿主的免疫状态可能介导这种关系。减少接触重金属可能对持续性感染具有预防意义。需要进一步的前瞻性研究来证实这些发现.
UNASSIGNED: Persistent infections caused by certain viruses and parasites have been associated with multiple diseases and substantial mortality. Heavy metals are ubiquitous environmental pollutants with immunosuppressive properties. This study aimed to determine whether heavy metals exposure suppress the immune system, thereby increasing the susceptibility to persistent infections.
UNASSIGNED: Using data from NHANES 1999-2016, we explored the associations between heavy metals exposure and persistent infections: Cytomegalovirus (CMV), Epstein-Barr Virus (EBV), Hepatitis C Virus (HCV), Herpes Simplex Virus Type-1 (HSV-1), Toxoplasma gondii (T. gondii), and Toxocara canis and Toxocara cati (Toxocara spp.) by performing logistic regression, weighted quantile sum (WQS) and Bayesian kernel machine regression (BKMR) models. Mediation analysis was used to determine the mediating role of host immune function in these associations.
UNASSIGNED: Logistic regression analysis revealed positive associations between multiple heavy metals and the increased risk of persistent infections. In WQS models, the heavy metals mixture was associated with increased risks of several persistent infections: CMV (OR: 1.58; 95% CI: 1.17, 2.14), HCV (OR: 2.94; 95% CI: 1.68, 5.16), HSV-1 (OR: 1.25; 95% CI: 1.11, 1.42), T. gondii (OR: 1.97; 95% CI: 1.41, 2.76), and Toxocara spp. (OR: 1.76; 95% CI: 1.16, 2.66). BKMR models further confirmed the combined effects of heavy metals mixture and also identified the individual effect of arsenic, cadmium, and lead. On mediation analysis, the systemic immune inflammation index, which reflects the host\'s immune status, mediated 12.14% of the association of mixed heavy metals exposure with HSV-1 infection.
UNASSIGNED: The findings of this study revealed that heavy metals exposure may increase susceptibility to persistent infections, with the host\'s immune status potentially mediating this relationship. Reducing exposure to heavy metals may have preventive implications for persistent infections, and further prospective studies are needed to confirm these findings.