Abstract：
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic polyarticular pain, and its main pathological features include inflammatory cell infiltration, synovial fibroblast proliferation, and cartilage erosion. Immune cells, synovial cells and neuroendocrine factors play pivotal roles in the pathophysiological mechanism underlying rheumatoid arthritis. Biological clock genes regulate immune cell functions, which is linked to rhythmic changes in arthritis pathology. Additionally, the interaction between biological clock genes and neuroendocrine factors is also involved in rhythmic changes in rheumatoid arthritis. This review provides an overview of the contributions of circadian rhythm genes to RA pathology, including their interaction with the immune system and their involvement in regulating the secretion and function of neuroendocrine factors. A molecular understanding of the role of the circadian rhythm in RA may offer insights for effective disease management.
摘要：
类风湿性关节炎（RA）是一种以全身性多关节疼痛为特征的慢性自身免疫性疾病，其主要病理特征包括炎性细胞浸润,滑膜成纤维细胞增殖，和软骨侵蚀。免疫细胞,滑膜细胞和神经内分泌因子在类风湿性关节炎的病理生理机制中起着关键作用。生物钟基因调节免疫细胞功能，这与关节炎病理的节律变化有关。此外,生物钟基因与神经内分泌因子之间的相互作用也参与类风湿性关节炎的节律性改变。本文综述了昼夜节律基因对RA病理的贡献。包括它们与免疫系统的相互作用以及它们参与调节神经内分泌因子的分泌和功能。对昼夜节律在RA中的作用的分子理解可能为有效的疾病管理提供见解。
