■清热祛湿中药(HDCM)在宫颈HPV感染的临床试验中已经研究了数十年。然而,对证据的强度和质量几乎没有全面评估。因此,这项研究进行了系统评价和荟萃分析,以评估HDCM在高危型宫颈HPV感染患者中的有效性和安全性.
■研究焦点问题是根据参与者的标准构建的,干预,比较,和结果(PICO),并且在PROSPERO注册了协议。从成立到2022年6月30日,对八个电子数据库进行了全面和系统的搜索和查询。Further,我们对所有随机对照试验(RCT)进行了系统评价和荟萃分析,以评估HDCM治疗方法.
■共有12项研究符合纳入条件,包括1574名患者。数据综合显示,HDCM组的HPV清除率均优于干扰素组和随访组(RR=1.40,95%CI:1.15,1.71,P<0.01)和(RR=3.15,95%CI:2.43,4.08,P<0.01)。分别。证明HDCM在降低HPV-DNA病毒载量方面表现出更大的潜力(MD=-5.16,95%CI:-5.91,-4.41,P<0.01)。HDCM组宫颈上皮内瘤变(CIN)逆转率约为2.8倍(RR=2.80,95%CI:2.19,3.57,P<0.01),与后续小组一样高。此外,据报道,在这项荟萃分析中,HDCM组的HR-HPV复发率低于随访组[6.81%(16/235)和14.65%(29/198),分别]。最常用的中草药如下:黄柏(黄柏。GlabriusculumC.K.Schneid.),苦参(苦参),大青叶(板蓝根财富),Zicao(ArnebiaHi-spidissimaDC。),白花蛇草(白花蛇舌草。),板蓝根(板蓝根。tinctoriaL.),胡章(日本雷诺特。),和黄旗(奥班奇黄芪)。
■HDCM干预似乎对提高HR-HPV清除率产生了显着影响,减少HPV-DNA病毒载量,并提高CIN回归率。一些活性成分被证实是造成这种疗效的原因,值得进一步探索。
■https://www.crd.约克。AC.英国/PROSPERO/,标识符:CRD4202233226。
UNASSIGNED: Heat-clearing and dampness-eliminating Chinese medicine (HDCM) has been studied in clinical trials for cervical HPV infection for decades. However, there has been little comprehensive assessment of the strength and quality of the evidence. Therefore, this study conducted a systematic review and meta-analysis to assess the effectiveness and safety of HDCM in high-risk cervical HPV-infected patients.
UNASSIGNED: The research focus questions were constructed in accordance with the criteria of participants, intervention, comparison, and outcomes (PICO), and a protocol was registered in PROSPERO. Comprehensive and systematic searches and inquiries in eight electronic databases were conducted from their inception to 30th June 2022. Further, a systematic review and meta-analysis of all randomized controlled trials (RCTs) were conducted to evaluate the HDCM therapy methods.
UNASSIGNED: A total of 12 studies were eligible for inclusion, including 1,574 patients. Data synthesis showed that the HPV clearance rate of HDCM groups was superior to both interferon and follow-up groups (RR = 1.40,95% CI:1.15, 1.71, P < 0.01) and (RR = 3.15, 95% CI:2.43,4.08, P < 0.01), respectively. HDCM was proven to exhibit greater potential in reducing HPV-DNA virus load (MD = -5.16, 95% CI: -5.91, -4.41, P < 0.01). The reversal rate of cervical intraepithelial neoplasia (CIN) for HDCM groups was approximately 2.8 times (RR = 2.80, 95% CI: 2.19, 3.57, P < 0.01), as high as the follow-up groups. Additionally, the recurrence rate of HR-HPV at the end of follow-up in this meta-analysis was reported to be lower in HDCM groups compared to follow-up groups [6.81% (16/235) and 14.65% (29/198), respectively]. The most commonly used Chinese herbal remedies were as follows: Huangbai (Phellodendron chinense var.Glabriusculum C.K. Schneid.), Kushen (Sophora flavescens Aiton), Daqingye (Isatis indigotica Fortune), Zicao (Arnebia hi-spidissima DC.), Baihuasheshecao (Hedyotis diffusa Spreng.), Banlangen (Isatis tinctoria subsp.tinctoria L.), Huzhang (Reynoutria japonica Houtt.), and Huangqi (Orobanche astragali Mouterde).
UNASSIGNED: HDCM interventions appeared to generate significant effects on enhancing the rate of HR-HPV clearance, reducing the HPV-DNA virus load, and increasing the CIN regression rate. Some active components were confirmed to be responsible for this efficacy, which deserves further exploration.
UNASSIGNED: https://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42022333226.