{Reference Type}: Journal Article
{Title}: A comparative study of treatment of cervical low-grade squamous intraepithelial lesions (LSIL).
{Author}: Chen Y;Dong Z;Yuan L;Xu Y;Cao D;Xiong Z;Zhang Z;Wu D;
{Journal}: Photodiagnosis Photodyn Ther
{Volume}: 45
{Issue}: 0
{Year}: 2024 Feb 2
{Factor}: 3.577
{DOI}: 10.1016/j.pdpdt.2023.103920
{Abstract}: <B>OBJECTIVE: </B>Low-grade squamous intraepithelial lesion (LSIL) is one of two categories of cervical intraepithelial lesions. Given that controversy exists regarding its management, this comparative study aimed to evaluate the effect of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in treating LSIL of the high-risk human papillomavirus (HR-HPV)-infected cervix.<BR><B>METHODS: </B>A total of 218 patients (25-45 years old) with cervical LSIL associated with HR-HPV who underwent ALA-PDT, loop electrosurgical excision procedure (LEEP), or observation only were included. The clearance rates of cervical LSIL and HR-HPV between the ALA-PDT, LEEP, and observation groups were compared at 6 and 12 months follow-up. Adverse reactions were also compared. The factors affecting the clearance on ALA-PDT of cervical LSIL were evaluated.<BR><B>RESULTS: </B>There were no statistically significant differences in lesion and HR-HPV clearance rates between the ALA-PDT and LEEP groups at 6 and 12 months. However, the lesion and HR-HPV clearance rates were significantly higher in the ALA-PDT group than that in the observation group. The adverse reaction rate was significantly lower in the ALA-PDT group than in the LEEP group.<BR><B>CONCLUSIONS: </B>For patients with cervical LSIL, the lesion and HR-HPV clearance rates after ALA-PDT were close to those after LEEP and significantly higher than in the observation group. Moreover, the adverse reaction rate for ALA-PDT was much lower than that for LEEP. Therefore, ALA-PDT provides a new option for the minimally invasive treatment of cervical LSIL.