Abstract：
OBJECTIVE: Low-grade squamous intraepithelial lesion (LSIL) is one of two categories of cervical intraepithelial lesions. Given that controversy exists regarding its management, this comparative study aimed to evaluate the effect of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in treating LSIL of the high-risk human papillomavirus (HR-HPV)-infected cervix.
METHODS: A total of 218 patients (25-45 years old) with cervical LSIL associated with HR-HPV who underwent ALA-PDT, loop electrosurgical excision procedure (LEEP), or observation only were included. The clearance rates of cervical LSIL and HR-HPV between the ALA-PDT, LEEP, and observation groups were compared at 6 and 12 months follow-up. Adverse reactions were also compared. The factors affecting the clearance on ALA-PDT of cervical LSIL were evaluated.
RESULTS: There were no statistically significant differences in lesion and HR-HPV clearance rates between the ALA-PDT and LEEP groups at 6 and 12 months. However, the lesion and HR-HPV clearance rates were significantly higher in the ALA-PDT group than that in the observation group. The adverse reaction rate was significantly lower in the ALA-PDT group than in the LEEP group.
CONCLUSIONS: For patients with cervical LSIL, the lesion and HR-HPV clearance rates after ALA-PDT were close to those after LEEP and significantly higher than in the observation group. Moreover, the adverse reaction rate for ALA-PDT was much lower than that for LEEP. Therefore, ALA-PDT provides a new option for the minimally invasive treatment of cervical LSIL.
METHODS: A total of 218 patients (25-45 years old) with cervical LSIL associated with HR-HPV who underwent ALA-PDT, loop electrosurgical excision procedure (LEEP), or observation only were included. The clearance rates of cervical LSIL and HR-HPV between the ALA-PDT, LEEP, and observation groups were compared at 6 and 12 months follow-up. Adverse reactions were also compared. The factors affecting the clearance on ALA-PDT of cervical LSIL were evaluated.
RESULTS: There were no statistically significant differences in lesion and HR-HPV clearance rates between the ALA-PDT and LEEP groups at 6 and 12 months. However, the lesion and HR-HPV clearance rates were significantly higher in the ALA-PDT group than that in the observation group. The adverse reaction rate was significantly lower in the ALA-PDT group than in the LEEP group.
CONCLUSIONS: For patients with cervical LSIL, the lesion and HR-HPV clearance rates after ALA-PDT were close to those after LEEP and significantly higher than in the observation group. Moreover, the adverse reaction rate for ALA-PDT was much lower than that for LEEP. Therefore, ALA-PDT provides a new option for the minimally invasive treatment of cervical LSIL.
摘要：
目的：低度鳞状上皮内病变（LSIL）是宫颈上皮内病变的两类之一。鉴于其管理存在争议，本比较研究旨在评估5-氨基酮戊酸光动力疗法(ALA-PDT)治疗高危型人乳头瘤病毒(HR-HPV)感染宫颈LSIL的疗效.
方法：共有218例（25-45岁）宫颈LSIL伴HR-HPV患者行ALA-PDT，环形电切术（LEEP），或仅包括观察。宫颈LSIL和HR-HPV在ALA-PDT、LEEP,观察组随访6个月和12个月时进行比较。也比较了不良反应。评价影响宫颈LSILALA-PDT清除率的因素。
结果：在6个月和12个月时，ALA-PDT组和LEEP组之间的病变和HR-HPV清除率无统计学差异。然而,ALA-PDT组的病变和HR-HPV清除率明显高于观察组。ALA-PDT组不良反应发生率明显低于LEEP组。
结论：对于宫颈LSIL患者，ALA-PDT后病变和HR-HPV清除率与LEEP后接近,且明显高于观察组.此外，ALA-PDT的不良反应发生率远低于LEEP.因此,ALA-PDT为宫颈LSIL的微创治疗提供了新的选择。
方法：共有218例（25-45岁）宫颈LSIL伴HR-HPV患者行ALA-PDT，环形电切术（LEEP），或仅包括观察。宫颈LSIL和HR-HPV在ALA-PDT、LEEP,观察组随访6个月和12个月时进行比较。也比较了不良反应。评价影响宫颈LSILALA-PDT清除率的因素。
结果：在6个月和12个月时，ALA-PDT组和LEEP组之间的病变和HR-HPV清除率无统计学差异。然而,ALA-PDT组的病变和HR-HPV清除率明显高于观察组。ALA-PDT组不良反应发生率明显低于LEEP组。
结论：对于宫颈LSIL患者，ALA-PDT后病变和HR-HPV清除率与LEEP后接近,且明显高于观察组.此外，ALA-PDT的不良反应发生率远低于LEEP.因此,ALA-PDT为宫颈LSIL的微创治疗提供了新的选择。
