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Abstract：
This study aims to investigate the relationship between abnormal vaginal microecology and human papillomavirus (HPV) infection, as well as the squamous intraepithelial lesions (SIL) progression.
A total of 383 patients diagnosed with HPV infection in our hospital between March 2017 and February 2022 were selected as the experimental group. In addition, several volunteers (n = 898) who underwent physical examination during the same period were randomly selected as the control group. Subsequently, we conducted several investigations, such as HPV detection and gene typing, examined vaginal microecological imbalances, and performed cytological examinations to analyze the correlation between microecological changes, different types of HPV infection, and SIL progression.
HPV detection primarily included single and high-risk types of HPV infections. Moreover, significant disparities in the vaginal microecological environment between patients with persistent HPV infection and the control group, as well as patients with low-grade and high-grade SIL (LSIL and HSIL), were observed. The regression analysis revealed a correlation between LSIL and microflora density, diversity, bacteriological vaginosis (BV), vulvovaginal candidiasis (VVC), trichomonas vaginalis (TV), sialidase, as well as Lactobacillus. In addition, we identified an association between HSIL and pH, flora density, diversity, BV, VVC, candida vaginitis (CV), leukocyte esterase, catalase, and Lactobacillus levels.
These findings revealed a significant association between abnormal vaginal microecology and both HPV infection and the SIL progression.
A total of 383 patients diagnosed with HPV infection in our hospital between March 2017 and February 2022 were selected as the experimental group. In addition, several volunteers (n = 898) who underwent physical examination during the same period were randomly selected as the control group. Subsequently, we conducted several investigations, such as HPV detection and gene typing, examined vaginal microecological imbalances, and performed cytological examinations to analyze the correlation between microecological changes, different types of HPV infection, and SIL progression.
HPV detection primarily included single and high-risk types of HPV infections. Moreover, significant disparities in the vaginal microecological environment between patients with persistent HPV infection and the control group, as well as patients with low-grade and high-grade SIL (LSIL and HSIL), were observed. The regression analysis revealed a correlation between LSIL and microflora density, diversity, bacteriological vaginosis (BV), vulvovaginal candidiasis (VVC), trichomonas vaginalis (TV), sialidase, as well as Lactobacillus. In addition, we identified an association between HSIL and pH, flora density, diversity, BV, VVC, candida vaginitis (CV), leukocyte esterase, catalase, and Lactobacillus levels.
These findings revealed a significant association between abnormal vaginal microecology and both HPV infection and the SIL progression.
摘要：
目的：本研究旨在探讨阴道微生态异常与人乳头瘤病毒（HPV）感染的关系。以及鳞状上皮内病变（SIL）进展。
方法：选取2017年3月至2022年2月我院确诊为HPV感染的383例患者作为试验组。此外,随机选择同期接受体检的志愿者(n=898)作为对照组。随后，我们进行了几次调查，如HPV检测和基因分型，检查阴道微生态失衡，并进行细胞学检查以分析微生态变化之间的相关性，不同类型的HPV感染，和SIL进展。
结果：HPV检测主要包括单一和高危HPV感染类型。此外，持续HPV感染患者的阴道微生态环境与对照组之间存在显着差异，以及低级别和高级别SIL（LSIL和HSIL）患者，被观察到。回归分析显示LSIL与微生物群落密度之间存在相关性，多样性,细菌性阴道病（BV），外阴阴道念珠菌病（VVC），阴道毛滴虫（TV），唾液酸酶,以及乳酸菌。此外,我们确定了HSIL和pH之间的关联，菌群密度,多样性,BV,VVC,念珠菌阴道炎（CV），白细胞酯酶，过氧化氢酶,和乳酸菌水平。
结论：这些发现揭示了异常阴道微生态与HPV感染和SIL进展之间的显著关联。
方法：选取2017年3月至2022年2月我院确诊为HPV感染的383例患者作为试验组。此外,随机选择同期接受体检的志愿者(n=898)作为对照组。随后，我们进行了几次调查，如HPV检测和基因分型，检查阴道微生态失衡，并进行细胞学检查以分析微生态变化之间的相关性，不同类型的HPV感染，和SIL进展。
结果：HPV检测主要包括单一和高危HPV感染类型。此外，持续HPV感染患者的阴道微生态环境与对照组之间存在显着差异，以及低级别和高级别SIL（LSIL和HSIL）患者，被观察到。回归分析显示LSIL与微生物群落密度之间存在相关性，多样性,细菌性阴道病（BV），外阴阴道念珠菌病（VVC），阴道毛滴虫（TV），唾液酸酶,以及乳酸菌。此外,我们确定了HSIL和pH之间的关联，菌群密度,多样性,BV,VVC,念珠菌阴道炎（CV），白细胞酯酶，过氧化氢酶,和乳酸菌水平。
结论：这些发现揭示了异常阴道微生态与HPV感染和SIL进展之间的显著关联。
