■光化性角化病(AK)是由慢性日晒引起的恶性皮肤病变,由5-氟尿嘧啶(5-FU)局部管理,双氯芬酸3%凝胶,还有咪喹莫特.尽管他们的有效性,治疗时间长和严重的不良局部皮肤反应限制了患者的一致性。卡泊三醇最近已被用作现有局部AK治疗的组合剂。进行了系统评价以确定5-FU和卡泊三醇治疗AK的临床疗效。Bowen病,鳞状细胞癌(SCC)。
■在Medline上进行了系统的文献检索,Embase,科克伦图书馆在筛选的84条记录中,检索到12项用于全文审查,其中8项纳入最终分析。
■在8项研究中,214例对照患者和288例接受干预的患者.5%5-FU与卡泊三醇的组合导致面部AK的数量显着减少,头皮,右上肢,8周时所有部位的左上肢(P<0.0001)。在1年或2年时没有观察到SCC发病率的显著差异,但是在3年时观察到面部和头皮上的SCC显着减少。没有研究评估Bowen病的组合。
■5%5-FU与卡泊三醇的组合是Aks的有效治疗方法;但是,未来的试验可能会考虑更长的治疗和随访时间来治疗和预防AK,原位SCC,SCC。
UNASSIGNED: Actinic keratoses (AK) are premalignant skin lesions caused by chronic sun exposure, topically managed by 5-fluorouracil (5-FU), diclofenac 3% gel, and imiquimod. Despite their effectiveness, long treatment duration and severe adverse local skin reactions have limited patient concordance. Calcipotriol has recently been used as a combination agent for existing topical AK treatments. A systematic
review was performed to determine the clinical efficacy of 5-FU and calcipotriol for the treatment of AK, Bowen\'s disease, and squamous cell carcinoma (SCC).
UNASSIGNED: A systematic literature search was conducted on Medline, Embase, and Cochrane Library. Among the 84 records screened, 12 were retrieved for full-text
review and 8 were included in the final analysis.
UNASSIGNED: Among the 8 studies, there were 214 control patients and 288 patients who received the intervention. The combination 5% 5-FU with calcipotriol resulted in a significant reduction in the number of AKs on the face, scalp, right upper extremity, and left upper extremity for all sites at 8 weeks (P < .0001). No significant difference in SCC incidence was observed at 1 or 2 years, but there was a significant reduction observed at 3 years for SCC on face and scalp. No study assessed the combination for Bowen\'s disease.
UNASSIGNED: Combination 5% 5-FU with calcipotriol is an effective treatment for Aks; however, future trials may consider longer treatment and follow-up periods for the treatment and prevention of AK, SCC in situ, and SCC.