Abstract：
Vitamin D (VD) deficiency has been associated with various tumors. However, the association between VD and skin cancer is controversial. Although in non-melanoma skin cancer, adequate or even high levels of VD can be associated with a higher risk of developing tumors, this could be biased by the direct association between sun exposure and VD levels. Regarding melanoma, results are contradictory. Most studies analyzed state that higher levels of VD could reduce the risk of melanoma, be associated with melanomas with better prognosis and with an enhanced antitumor response, and also with fewer adverse events associated with melanoma immunotherapy. However, prospective studies of adequate methodological quality are still needed to assess the association between VD levels and its supplementation and development/prognosis in skin cancer.
摘要：
维生素D（VD）缺乏与各种肿瘤有关。然而,VD与皮肤癌之间的关联存在争议.尽管在非黑色素瘤皮肤癌中，足够或甚至高水平的VD可能与更高的发展肿瘤的风险有关，这可能是由于阳光照射和VD水平之间的直接关联而产生的偏差。关于黑色素瘤，结果是矛盾的。大多数研究分析表明，较高水平的VD可以降低黑色素瘤的风险，与具有更好预后和增强的抗肿瘤反应的黑色素瘤相关，与黑色素瘤免疫治疗相关的不良事件也较少。然而,仍需要足够方法学质量的前瞻性研究来评估VD水平及其补充剂与皮肤癌发展/预后之间的关联.
