Abstract：
Skin cancers are associated with a large number of genodermatoses. Existing knowledge and guidelines on the presentations of these genodermatoses focus disproportionately on White patients. Our goal is to identify notable characteristics in location, frequency, and severity of cutaneous findings along with the median age of skin cancers in skin-of-color (SOC) patients with skin-cancer-associated genodermatoses to improve diagnosis rates. We searched for genodermatoses on six databases. Each case report or case series was reviewed, including reports, published in English, containing adult patient descriptions. Duplicate manuscripts were removed using EndNote. The following case-level data were collected from the manuscripts: age, gender, patient country or region of origin, author country/continent of residence, skin cancer-related, and other key dermatologic features. 381 published articles, with a total of 578 SOC patients, met criteria for inclusion. SOC patients can present with fewer classic findings, such as a lower incidence of basal cell carcinomas (44%) in SOC Gorlin syndrome patients than palmar pits (66%) and mandibular cysts (66%). Differences between SOC populations were also noted, such as leukoplakia being more common in Asian dyskeratosis congenita patients (80%) in comparison to African dyskeratosis congenita patients (44%). SOC patients also have varying onset of skin cancer depending on the genodermatosis, from a median of 25 years of age in Rothmund-Thomson syndrome to 53 in Muir-Torre syndrome. In this review, SOC patients with genodermatoses can have varying presentations. Being cognizant of these characteristics may lead to earlier diagnosis and interventions to mitigate skin-cancer-related morbidity in SOC patients.
摘要：
皮肤癌与大量遗传性皮肤病有关。关于这些遗传性皮肤病表现的现有知识和指南不成比例地集中在白人患者身上。我们的目标是确定位置的显着特征，频率,和皮肤发现的严重程度以及皮肤癌相关遗传性皮肤病的皮肤（SOC）患者的皮肤癌中位年龄，以提高诊断率。我们在六个数据库中搜索了遗传性皮肤病。审查了每个病例报告或病例系列，包括报告,以英文出版,包含成人患者描述。使用EndNote删除了重复的手稿。从手稿中收集了以下病例级别的数据：年龄，性别,患者所在国家或地区，作者国家/居住大陆，皮肤癌相关，和其他关键的皮肤病学特征。发表了381篇文章，共有578名SOC患者，符合纳入标准。SOC患者可以呈现较少的经典发现，如SOCGorlin综合征患者基底细胞癌(44%)的发生率低于掌窝(66%)和下颌囊肿(66%)。还注意到SOC人群之间的差异，例如，与非洲先天性角化障碍患者（44％）相比，亚洲先天性角化障碍患者（80％）更常见白斑。SOC患者也有不同的皮肤癌发作取决于遗传性皮肤病，从Rothmund-Thomson综合征的中位年龄25岁到Muir-Torre综合征的中位年龄53岁。在这次审查中,患有遗传性皮肤病的SOC患者可以有不同的表现。认识到这些特征可能导致早期诊断和干预以减轻SOC患者中皮肤癌相关的发病率。
