Abstract：
BACKGROUND: This systematic review assessed the effectiveness of photodynamic therapy (PDT) in patients with recurrent oral squamous cell carcinoma (OSCC).
METHODS: Clinical studies on recurrent OSCC treated with PDT alone were included. Combined treatment strategies were excluded. The search was performed on Medline/Pubmed, Cochrane Library, Embase, Web of Science and ClinicalTrials.gov, manual search, and grey literature.
RESULTS: The eleven included studies were observational. The risk of bias and methodological quality were evaluated using the Newcastle-Ottawa Quality Assessment Scale. The studies reported the use of hematoporphyrin derivative, PhotofrinⓇ, FoscanⓇ and 5-aminolevulinic acid. Data on treatment response and survival was collected. Secondarily, postoperative courses and patient\'s quality of life/acceptance were reported whenever available. PhotofrinⓇ and FoscanⓇ were the most used photosensitisers, with more complete responses. Lesions responding less favourably were on posterior regions or deep-seated in the tissue.
CONCLUSIONS: Although treatment response differs between treatment protocols, PDT stands as a viable treatment option to be considered, as it can achieve therapeutic results and disease-free, long-lasting periods. Partial treatment responses may be of interest when achieving eligibility for other treatment strategies. Despite this study\'s limitations, which considered four photosensitisers, PhotofrinⓇ was the most used but more recent photosensitisers like FoscanⓇ have greater chemical stability, tissue penetration, and may be more efficacious on recurrent OSCC.
METHODS: Clinical studies on recurrent OSCC treated with PDT alone were included. Combined treatment strategies were excluded. The search was performed on Medline/Pubmed, Cochrane Library, Embase, Web of Science and ClinicalTrials.gov, manual search, and grey literature.
RESULTS: The eleven included studies were observational. The risk of bias and methodological quality were evaluated using the Newcastle-Ottawa Quality Assessment Scale. The studies reported the use of hematoporphyrin derivative, PhotofrinⓇ, FoscanⓇ and 5-aminolevulinic acid. Data on treatment response and survival was collected. Secondarily, postoperative courses and patient\'s quality of life/acceptance were reported whenever available. PhotofrinⓇ and FoscanⓇ were the most used photosensitisers, with more complete responses. Lesions responding less favourably were on posterior regions or deep-seated in the tissue.
CONCLUSIONS: Although treatment response differs between treatment protocols, PDT stands as a viable treatment option to be considered, as it can achieve therapeutic results and disease-free, long-lasting periods. Partial treatment responses may be of interest when achieving eligibility for other treatment strategies. Despite this study\'s limitations, which considered four photosensitisers, PhotofrinⓇ was the most used but more recent photosensitisers like FoscanⓇ have greater chemical stability, tissue penetration, and may be more efficacious on recurrent OSCC.
摘要：
背景：这项系统评价评估了光动力疗法（PDT）在复发性口腔鳞状细胞癌（OSCC）患者中的有效性。
方法：纳入单纯PDT治疗复发性OSCC的临床研究。排除联合治疗策略。搜索是在Medline/Pubmed上进行的，科克伦图书馆,Embase,WebofScienceandClinicalTrials.gov,手动搜索,灰色文学
结果：纳入的11项研究均为观察性研究。使用纽卡斯尔-渥太华质量评估量表评估偏倚风险和方法学质量。研究报道了血卟啉衍生物的使用，Photofrin®,Foscan®和5-氨基乙酰丙酸。收集关于治疗反应和存活的数据。其次，我们报告了术后疗程和患者的生活质量/接受情况.Photofrin®和Foscan®是最常用的光敏剂，计算更完整的回答。病变反应较差的是后部区域或组织深处。
结论：尽管不同治疗方案的治疗反应不同，PDT是一种可行的治疗选择，因为它可以达到治疗效果和无疾病，持久的时期。当实现其他治疗策略的资格时,部分治疗反应可能是感兴趣的。尽管这项研究的局限性考虑四种光敏剂，Photofrin®是最常用的，但最近的光敏剂，如Foscan具有更大的化学稳定性，组织渗透，对复发性OSCC可能更有效。
方法：纳入单纯PDT治疗复发性OSCC的临床研究。排除联合治疗策略。搜索是在Medline/Pubmed上进行的，科克伦图书馆,Embase,WebofScienceandClinicalTrials.gov,手动搜索,灰色文学
结果：纳入的11项研究均为观察性研究。使用纽卡斯尔-渥太华质量评估量表评估偏倚风险和方法学质量。研究报道了血卟啉衍生物的使用，Photofrin®,Foscan®和5-氨基乙酰丙酸。收集关于治疗反应和存活的数据。其次，我们报告了术后疗程和患者的生活质量/接受情况.Photofrin®和Foscan®是最常用的光敏剂，计算更完整的回答。病变反应较差的是后部区域或组织深处。
结论：尽管不同治疗方案的治疗反应不同，PDT是一种可行的治疗选择，因为它可以达到治疗效果和无疾病，持久的时期。当实现其他治疗策略的资格时,部分治疗反应可能是感兴趣的。尽管这项研究的局限性考虑四种光敏剂，Photofrin®是最常用的，但最近的光敏剂，如Foscan具有更大的化学稳定性，组织渗透，对复发性OSCC可能更有效。
