背景:膝骨关节炎(KOA)是一种慢性关节退行性疾病。透明质酸(HA)的关节内注射(IAI)被广泛用于治疗KOA。然而,一些HA注射根本没有效果。多核苷酸(PN)最近被认为是HA的有效替代品。
方法:一名61岁女性进入疼痛中心,症状为膝盖疼痛,左膝盖有僵硬的温暖感。尽管HA的IAI是其的6倍,但患者仍报告了左膝区域的慢性严重疼痛。她有乳腺癌和甲状腺癌病史。
方法:她被诊断为患有KOA。
方法:超声引导下PN的IAI在3周内进行3次。
结果:随访5个月以上,顽固性膝关节疼痛改善良好,无任何不良事件。
结论:如果HA注射不成功,PN的IAI是KOA治疗的有效治疗选择。
BACKGROUND: Knee osteoarthritis (KOA) is a chronic joint degenerative disease. Intra-articular injection (IAI) of hyaluronic acid (HA) is widely used to treat KOA. However, some HA injections have no effect at all.
Polynucleotides (PN) are recently noted as a valid substitute for HA.
METHODS: A 61-year-old female was admitted to the pain center with symptoms of pain over the knee and warmth feeling with stiffness in the left knee. The patient reported chronic severe pain in the left knee area despite 6 times IAI of HA. She had past medical history of breast cancer and thyroid cancer.
METHODS: She was diagnosed as having KOA.
METHODS: Ultrasound-guided IAI of PN was carried out 3 times in 3 weeks.
RESULTS: She was followed-up for more than 5 months with good improvement in intractable knee pain without any adverse event.
CONCLUSIONS: IAI of PN is an efficient therapeutic option for KOA treatment if HA injection is unsuccessful.