背景:活动范围减小和疼痛是骨关节炎(OA)的最典型临床特征。透明质酸(HA),这是OA治疗的浸润性疗法之一,和多核苷酸(PN),这是一种DNA衍生的大分子,有利于细胞生长和胶原蛋白的产生,是临床有效性的持续辩论。
方法:我们计划对随机临床试验进行系统评价和荟萃分析,以评估与透明质酸相关的关节内多核苷酸与单独透明质酸治疗膝骨关节炎的疗效。我们将搜索PubMed,EMBASE,Cochrane图书馆采用综合策略。还将检查相关的会议记录和所包括研究的参考清单,以确定其他研究。两名审阅者将筛选检索到的记录,提取信息并独立评估偏差风险。将使用Statav15.1软件进行数据合成。
结果:本研究将提交给同行评审的期刊发表。
结论:我们希望它能为临床实践和未来的相关临床试验提供相对全面的参考。
背景:不需要伦理批准和患者同意,因为这项研究是一项系统综述和荟萃分析。
■CRD42020167678。
BACKGROUND: The reduced range of motion and pain are the most characteristic clinical features of osteoarthritis (OA). Hyaluronic acid (HA), which is one of the infiltrative therapies for OA treatment, and
polynucleotides (PNs), which is a DNA-derived macromolecule favored cell growth and collagen production, are an ongoing debate in clinical effectiveness.
METHODS: We plan to perform a systematic review and meta-analysis of randomized clinical trial to evaluate efficacy of intra-articular
polynucleotides associated with hyaluronic acid versus hyaluronic acid alone in the treatment of knee osteoarthritis. We will search PubMed, EMBASE, Cochrane Library using a comprehensive strategy. The related conference proceedings and reference lists of the included studies will also be checked to identify additional studies. Two reviewers will screen retrieved records, extract information and assess the risk of bias independently. Stata v15.1 software will be used to conduct data synthesis.
RESULTS: This study will be submitted to a peer-reviewed journal for publication.
CONCLUSIONS: We hope it will provide a relatively comprehensive reference for clinical practice and future relevant clinical trials.
BACKGROUND: Ethics approval and patient consent are not required, as this study is a systematic review and meta-analysis.
UNASSIGNED: CRD42020167678.