Abstract：
Polynucleotides and Hyaluronic Acid (PN-HA) mixture showed several effects in modulation of healing process. The aim of this study was to assess the safety and clinical performance of PN-HA alone or in association with Deproteinized Bovine Bone Mineral (DBBM) with papillary preservation flaps (PPF) in the treatment of residual pockets. A total of 43 patients with 55 infra-bony defects were recruited; 30% were smokers. The mean baseline Probing Depth (PD) was 7.7 ±1.9 mm with a corresponding mean recession (Rec) of 1.9± 1.3 mm. The depth of infra-bony defect at the surgical measurement was 5.2±2.1 mm. DBBM was applied at 56% of the defects considered as not-containing based on clinical judgment. Healing was uneventful at all sites. After one year, PD reduction was 4.4±1.8 mm with a Rec increase of 1.0 ±0.8 mm. Detected bone fill at x-ray was 3.5 ± 1.9mm. The multilevel analysis showed that absence of smoking habits was associated with improved PD reduction (P =0.026) and bone gain (P= 0.039). PN-HA mixture is a safe product for periodontal surgery and seems to promote clinical benefit in the treatment of residual pockets associated to infra-bony defects.
摘要：
多核苷酸和透明质酸（PN-HA）混合物在调节愈合过程中显示出多种作用。这项研究的目的是评估PN-HA单独或与脱蛋白牛骨矿物质（DBBM）和乳头状保存皮瓣（PPF）联合治疗残留口袋的安全性和临床表现。总共招募了43例有55例骨下缺陷的患者；30％是吸烟者。平均基线探测深度（PD）为7.7±1.9mm，相应的平均凹陷（Rec）为1.9±1.3mm。手术测量时骨下缺损的深度为5.2±2.1mm。根据临床判断，DBBM应用于56%的不含缺陷。所有地点的愈合都很顺利。一年后,PD减少4.4±1.8mm,Rec增加1.0±0.8mm。X射线检测到的骨填充为3.5±1.9mm。多水平分析表明，没有吸烟习惯与改善的PD减少（P=0.026）和骨增加（P=0.039）有关。PN-HA混合物是牙周手术的安全产品，似乎可以促进与骨下缺损相关的残留口袋的治疗的临床益处。
