■母婴环境健康风险(MIEHR)中心的建立是为了解决生物,物理,社会,并建立了不成比例地影响黑人孕妇围产期健康的环境,这些地区的黑人孕妇在美国有记录的差异
■MIEHR队列正在招募非西班牙裔黑人和非西班牙裔白人孕妇,他们在休斯顿的主要产科医院分娩婴儿,德克萨斯州。在入学时,要求所有参与者提供化学[金属的尿液样本,可替宁,和多环芳烃(PAHs)]分析和血液样本。队列的一部分被要求提供口腔和阴道拭子,和粪便样本。问卷调查和电子健康记录数据收集有关怀孕期间居住地址历史的信息,妊娠史和产前护理,社会人口统计学和生活方式因素,歧视和压力的经历,社会支持的来源。使用参与者在怀孕期间住在哪里的信息,他们的邻里环境特征是有特点的。我们提供了整个队列的关键个人和邻居级别特征的摘要,以及分别为黑人和白人参与者。
■在2021年4月至2023年2月之间,招募了1,244名孕妇。几乎所有参与者都提供了尿液样本,略低于一半的参与者提供了血液样本。迄今为止,47%的参与者评估的PAH暴露模式显示出与以前的研究相比,取决于代谢物的不同水平。此外,分析表明,黑人和白人孕妇在歧视经历方面存在差异,压力,和社会支持水平,以及邻里特征。
■迄今为止,我们的发现突出了歧视经历中的种族差异,压力,和支持水平,以及邻里特征。队列的招募正在进行中,并且正在构建其他邻居指标。生物标本将分析金属和PAH代谢物(尿样),miRNA(血浆样品)和微生物组(口腔拭子)。一旦注册结束,计划进行正式评估,以阐明环境风险景观中的个人和社区水平特征,这些特征导致围产期健康的黑白差异。
UNASSIGNED: The Maternal and Infant Environmental Health Riskscape (MIEHR) Center was established to address the interplay among chemical and non-chemical stressors in the biological, physical, social, and built environments that disproportionately impact perinatal health among Black pregnant people in a large and diverse urban area with documented disparities in the U.S.
UNASSIGNED: The MIEHR cohort is recruiting non-Hispanic Black and non-Hispanic white pregnant people who deliver their infants at major obstetric hospitals in Houston, Texas. At enrollment, all participants are asked to provide urine samples for chemical [metals, cotinine, and polycyclic aromatic hydrocarbons (PAHs)] analyses and blood samples. A subset of the cohort is asked to provide oral and vaginal swabs, and fecal samples. Questionnaire and electronic health record data gather information about residential address history during pregnancy, pregnancy history and prenatal care, sociodemographic and lifestyle factors, experiences of discrimination and stress, and sources of social support. Using information on where a participant lived during their pregnancy, features of their
neighborhood environment are characterized. We provide summaries of key individual- and
neighborhood-level features of the entire cohort, as well as for Black and white participants separately.
UNASSIGNED: Between April 2021 and February 2023, 1,244 pregnant people were recruited. Nearly all participants provided urine samples and slightly less than half provided blood samples. PAH exposure patterns as assessed on 47% of participants thus far showed varying levels depending on metabolite as compared to previous studies. Additionally, analyses suggest differences between Black and white pregnant people in experiences of discrimination, stress, and levels of social support, as well as in
neighborhood characteristics.
UNASSIGNED: Our findings to date highlight racial differences in experiences of discrimination, stress, and levels of support, as well as neighborhood characteristics. Recruitment of the cohort is ongoing and additional
neighborhood metrics are being constructed. Biospecimens will be analyzed for metals and PAH metabolites (urine samples), miRNAs (plasma samples) and the microbiome (oral swabs). Once enrollment ends, formal assessments are planned to elucidate individual- and
neighborhood-level features in the environmental riskscape that contribute to Black-White disparities in perinatal health.