目标:Musclin,最近被确认为Myokine,已被公认为其生理意义,通过竞争性抑制其清除受体来增强天然肽(NPs)的功能特性,纳命肽受体C(NPR-C)。这项研究,在文献中第一次,研究了人类有氧运动期间和之后肌肉的动态反应,在运动诱导的代谢反应的背景下,探索其作为肌动蛋白的潜力及其与NPs和NPR-C的相互作用。
方法:21名不活跃的年轻男性参加,我们评估了血清肌球蛋白水平的变化,心钠素(ANP),脑钠肽(BNP),肾上腺素(Epi),和甘油作为脂质动员的指标,在中等强度有氧运动期间和之后。此外,我们评估了NPR-C在皮下脂肪活检中的基因表达。
结果:有氧运动期间血清肌球蛋白水平显著升高,随后是复苏期间的下降,与基线相比仍然升高。发现肌肉反应和瘦体重(LBM)之间存在显著相关性,表明其通过骨骼肌质量和运动的调节。运动引起的肌肉变化与ANP呈正相关,潜在地防止ANP降解。此外,提示了NPR-C表达和肌肉动力学对ANP的潜在相互作用。然而,在运动过程中考虑其他脂解因素时,肌肉素对脂质动员的影响并不明显。
结论:Musclin作为一种肌动因子的分类受到其对有氧运动的反应及其与LBM的关联的支持。此外,其与NPR-C和NP的相互作用表明其生理相关性和潜在的临床意义。
OBJECTIVE: Musclin, recently identified as a
myokine, has been recognized for its physiological significance in potentiating the functional properties of natrieutic peptides (NPs) through competitive inhibition of their clearance receptor, natrieutic peptide receptor C (NPR-C). This study, for the first time in the literature, investigated the dynamic response of musclin during and after aerobic exercise in humans, exploring its potential as a
myokine and its interaction with NPs and NPR-C in the context of exercise-induced metabolic responses.
METHODS: Twenty-one inactive young males participated, and we assessed changes in serum levels of musclin, atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), epinephrine (Epi), and glycerol as an indicative of lipid mobilization, during and after moderate-intensity aerobic exercise. Furthermore, we evaluated the gene expression of NPR-C in subcutaneous fat biopsies.
RESULTS: Serum musclin levels increased significantly during aerobic exercise, followed by a decline during recovery, remaining elevated compared to baseline. Significant correlations were found between musclin responses and lean body mass (LBM), indicating its regulation by skeletal muscle mass and exercise. Exercise-induced changes in musclin positively correlated with those of ANP, potentially preventing ANP degradation. Additionally, a potential interplay between NPR-C expression and musclin dynamics on ANP was suggested. However, musclin\'s influence on lipid mobilization was not predominant when considering other lipolytic factors during exercise.
CONCLUSIONS: Musclin\'s classification as a
myokine is supported by its response to aerobic exercise and its association with LBM. Additionally, its interactions with NPR-C and NPs suggest its physiological relevance and potential clinical implications.