为临床前牙科材料研究研究开发偏见工具的风险,旨在支持未来调查的报告并改善系统评价的评估。
遵循EQUATOR网络建议的四阶段流程,其中包括项目启动,文献综述,Delphi过程和工具定稿。在欧洲保守牙科联合会(EFCD)和国际牙科研究协会(DMG-IADR)的牙科材料小组的支持下,共有26位专家利益相关者被纳入初始提案的制定和德尔福投票中。该提案是使用从文献综述阶段收集的数据构建的。在这个阶段,最近以牙科材料研究为特色的系统综述,以及文献中发现的偏见工具的风险被全面扫描为偏见源。因此,专家们就这些项目达成了共识,与工具相关的领域和判断,允许每个项目和相应的信号问题的详细指南。
该工具总共有九个项目,分布在4个域之间,与以下类型的偏差有关:与计划和分配相关的偏差(D1),试样制备(D2),结果评估(D3)和数据处理和结果报告(D4)。Robdemat,正如所呈现的,具有信号问题和可用于RoB判断的指南。它作为清单的使用优先于最终的总结分数。
RoBDEMAT是临床前牙科材料研究的第一个风险偏倚工具,得到该领域广泛的专家利益相关者的支持和发展,验证其未来用途。
这种新工具将通过提高牙科材料研究研究及其系统综述的科学质量和严谨性来为研究领域做出贡献。这些研究是未来临床研究和循证决策的基础和支持。
To develop a risk of bias tool for pre-clinical dental materials research studies that aims to support reporting of future investigations and improve assessment in systematic reviews.
A four-stage process following EQUATOR network recommendations was followed, which included project launch, literature review, Delphi process and the tool finalization. With the support of the European Federation of Conservative Dentistry (EFCD) and the Dental Materials Group of the International Association for Dental Research (DMG-IADR), a total of 26 expert stakeholders were included in the development and Delphi vote of the initial proposal. The proposal was built using data gathered from the literature review stage. During this stage, recent systematic reviews featuring dental materials research, and risk of bias tools found in the literature were comprehensively scanned for bias sources. The experts thus reached a
consensus for the items, domains and judgement related to the tool, allowing a detailed guide for each item and corresponding signalling questions.
The tool features nine items in total, spread between 4 domains, pertaining to the following types of bias: bias related to planning and allocation (D1), specimen preparation (D2), outcome assessment (D3) and data treatment and outcome reporting (D4). RoBDEMAT, as presented, features signalling questions and a guide that can be used for RoB judgement. Its use as a checklist is preferred over a final summary score.
RoBDEMAT is the first risk of bias tool for pre-clinical dental materials research, supported and developed by a broad group of expert stakeholders in the field, validating its future use.
This new tool will contribute the study field by improving the scientific quality and rigour of dental materials research studies and their systematic reviews. Such studies are the foundation and support of future clinical research and evidence-based decisions.