目的:从早期病例报告中发现,38%的二氟化银(SDF)在解决致病性生物膜和减轻牙龈炎症和肿大方面的潜在益处引起了人们的兴趣。我们的研究旨在评估38%SDF在减少居住在养老院的老年人牙龈炎症和斑块积聚方面的功效。
方法:这项为期7周的随机研究,控制,双盲试点试验采用并行分配设计。该研究招募了居住在达拉斯县养老院的老年人(年龄≥65岁),最终由40名参与者组成的队列,这些参与者被平均分成两组.实验组接受SDF治疗,而对照组则接受安慰剂.连续三周,两组均每周对所有牙齿的面部表面应用一次溶液.主要结果测量了基线治疗后7周的Löe-Silness牙龈指数(GI)和Silness-Löe菌斑指数(PI)的变化。利用重复测量ANOVA来评估各组内随时间的变化(每组n=15)。进行事后配对t检验,以比较第1周和随后每个随访时间点(第3、5、7周)之间的变化,从第1周开始的变化补充了95%的置信区间。
结果:在SDF组中,组内比较显示,3周内GI评分(-.93±.37)显着降低(调整后p<.05),与第1周相反(1.90±.39)。组间比较揭示了平均GI(p<.05)和PI(p<.05)的降低,表明在所有时间点SDF组中牙龈炎症和斑块积累较少,从第3周开始。
结论:这项研究表明,38%的SDF可有效减少居住在养老院的老年人的牙龈炎症和牙菌斑积聚。
结论:老年人的口腔健康是一个公共卫生问题,特别是对于医疗受损或没有传统护理的人。我们的发现为通过引入具有成本效益的口腔健康生活质量提供了希望,无合规性,非侵入性,和可获得的治疗。
背景:NCT03445286。(clinicaltrials.gov)。
Emerging from earlier case reports the potential benefits of 38 % silver diamine fluoride (SDF) in addressing pathogenic biofilms and mitigating gingival inflammation and enlargement have sparked interest. Our
study aimed to evaluate the efficacy of 38 % SDF in reducing gingival inflammation and plaque accumulation in older adults living in retirement-homes.
This 7-week randomized, controlled, double-blinded pilot
trial employed a parallel assignment design. The
study enrolled older adults (aged ≥65) residing in retirement homes in Dallas County, ultimately comprising a cohort of 40 participants who were evenly divided into two arms. The experimental group received SDF treatment, whereas the comparator group received a placebo. Over three consecutive weeks, both groups had solutions applied to the facial surfaces of all their teeth once per week. The primary outcomes measured the change in Löe-Silness Gingival Index (GI) and Silness-Löe Plaque Index (PI) at 7 weeks following baseline treatment. Repeated measures ANOVA was utilized to assess changes over time within each group (n = 15 each). Post-hoc paired t-tests were conducted to compare changes between week 1 and each subsequent follow-up time point (weeks 3, 5, 7), supplemented with 95 % confidence intervals for change from week 1.
In the SDF group, within-group comparisons demonstrated significant reductions (adjusted p < .05) in GI scores within 3 weeks (-.93±.37), as opposed to week 1 (1.90±.39). Between-group comparisons unveiled reductions in both mean GI (p < .05) and PI (p < .05), indicating less gingival inflammation and plaque accumulation in the SDF group at all time points, commencing at week 3.
This
study showed that 38 % SDF was effective in reducing gingival inflammation and plaque accumulation in older adults living in retirement-homes.
Oral health in older adults is a public health concern, especially for the medically compromised or those without traditional care. Our findings offer hope for enhancing oral health quality of life by introducing a cost-effective, compliance-free, noninvasive, and accessible therapeutic.
NCT03445286.(clinicaltrials.gov).