Abstract：
BACKGROUND: The clinical and radiographic efficacy of bone grafts and biomaterials, such as platelet-rich plasma and platelet-rich fibrin (PRF), for reconstructing lost periodontal structures has been well documented. However, there is limited data regarding the presence of demineralized freeze-dried bone allograft (DFDBA) in an environment with abundant growth factors provided by platelet concentrates.
OBJECTIVE: The aim of the study was to compare the clinical and radiographic effectiveness of DFDBA with PRF versus DFDBA alone in the treatment of intrabony defects.
METHODS: Twenty-four intrabony defects in contralateral sites were randomly assigned to either the DFDBA group or the DFDBA combined with PRF group. Clinical parameters, including the plaque index (PI), the gingival index (GI), probing pocket depth (PPD), relative attachment level (RAL), and radiographic bone fill (RBF), were measured at baseline, and at 6 and 9 months. Paired and unpaired t-tests were used for intraand intergroup comparisons.
RESULTS: Both the PI and the GI showed statistically significant improvements from baseline to 9 months. However, the intergroup comparisons did not reveal any significant differences (p < 0.05) between the groups with regard to clinical and radiographic measurements from baseline to 9 months.
CONCLUSIONS: Platelet-rich fibrin in combination with DFDBA did not show any additional benefit in terms of reconstructive output in the treatment of intrabony defects compared to the use of DFDBA alone.
OBJECTIVE: The aim of the study was to compare the clinical and radiographic effectiveness of DFDBA with PRF versus DFDBA alone in the treatment of intrabony defects.
METHODS: Twenty-four intrabony defects in contralateral sites were randomly assigned to either the DFDBA group or the DFDBA combined with PRF group. Clinical parameters, including the plaque index (PI), the gingival index (GI), probing pocket depth (PPD), relative attachment level (RAL), and radiographic bone fill (RBF), were measured at baseline, and at 6 and 9 months. Paired and unpaired t-tests were used for intraand intergroup comparisons.
RESULTS: Both the PI and the GI showed statistically significant improvements from baseline to 9 months. However, the intergroup comparisons did not reveal any significant differences (p < 0.05) between the groups with regard to clinical and radiographic measurements from baseline to 9 months.
CONCLUSIONS: Platelet-rich fibrin in combination with DFDBA did not show any additional benefit in terms of reconstructive output in the treatment of intrabony defects compared to the use of DFDBA alone.
摘要：
背景：骨移植物和生物材料的临床和影像学功效，如富血小板血浆和富血小板纤维蛋白（PRF），重建丢失的牙周结构已得到充分证明。然而,关于在血小板浓缩物提供丰富生长因子的环境中存在脱矿质冻干同种异体骨移植(DFDBA)的数据有限.
目的：本研究的目的是比较DFDBA和PRF与DFDBA单独治疗骨内缺损的临床和影像学效果。
方法：将24例对侧骨内缺损随机分配到DFDBA组或DFDBA联合PRF组。临床参数,包括菌斑指数（PI），牙龈指数(GI)，探测袋深度（PPD），相对附着水平(RAL)，和放射学骨填充(RBF)，在基线测量，6个月和9个月。配对和非配对t检验用于组内和组间比较。
结果：从基线到9个月，PI和GI均显示出统计学上的显着改善。然而,组间比较显示,从基线至9个月,两组间在临床和影像学测量方面无显著差异(p<0.05).
结论：与单独使用DFDBA相比，富血小板纤维蛋白与DFDBA联合治疗在重建输出方面没有显示出任何额外的益处。
目的：本研究的目的是比较DFDBA和PRF与DFDBA单独治疗骨内缺损的临床和影像学效果。
方法：将24例对侧骨内缺损随机分配到DFDBA组或DFDBA联合PRF组。临床参数,包括菌斑指数（PI），牙龈指数(GI)，探测袋深度（PPD），相对附着水平(RAL)，和放射学骨填充(RBF)，在基线测量，6个月和9个月。配对和非配对t检验用于组内和组间比较。
结果：从基线到9个月，PI和GI均显示出统计学上的显着改善。然而,组间比较显示,从基线至9个月,两组间在临床和影像学测量方面无显著差异(p<0.05).
结论：与单独使用DFDBA相比，富血小板纤维蛋白与DFDBA联合治疗在重建输出方面没有显示出任何额外的益处。
