辅酶Q10凝胶可能对牙周炎有益。然而,结果一直存在争议。我们设计了系统评价和荟萃分析,以探讨辅酶Q10在牙周炎患者中的疗效。
从1980年到2020年8月,由2名独立的研究人员通过以下数据库对对照试验(PROSPERO:CRD42020212424)进行了系统评价:Embase,中部,PubMed/MEDLINE,Scopus,WebofScience,谷歌学者,和ProQuest。还对所包括的研究的参考列表进行了手工搜索。269条记录中,采用随机效应模型的荟萃分析中纳入了11项试验.
辅酶Q10可以显着降低菌斑指数(SMD,-0.64;CI,-1.03至-0.26,P=.002;I2=85.7%),出血指数(SMD,-1.05;CI,-1.70至-0.41,P=.001;I2=89.5%),口袋深度(SMD,-0.96;CI,-1.35至-0.58,P<0.001,I2=84.7%),临床依恋水平(SMD,-0.73;CI,-1.23至-0.22,P=0.005;I2=87.8%),和牙龈指数(SMD,-0.63;CI,-0.97至-0.28,P=.001;I2=72.8%)在牙周炎中。亚组分析表明,如果在口袋内而不是局部给药,辅酶Q10具有更强的还原作用。与风险不明确的研究相比,具有高偏倚风险的研究报告辅酶Q10的积极作用更大。
我们的研究结果鼓励在牙周炎中使用辅酶Q10凝胶,因为它对菌斑指数有意义。出血指数,牙龈指数,临床依恋水平和口袋深度。未来的研究需要更好的质量,以获得更好的结论。
OBJECTIVE: Coenzyme Q10 gel might be beneficial for periodontitis. However, the results have been controversial. We designed a systematic
review and meta-analysis to explore the efficacy of coenzyme Q10 in periodontitis patients.
METHODS: A systematic
review of controlled trials (PROSPERO: CRD42020212424) was performed from 1980 to August 2020 by 2 separate investigators through the following databases: Embase, CENTRAL, PubMed/MEDLINE, Scopus, Web of Science, Google Scholar, and ProQuest. Hand search of reference lists of the included studies was also performed. Of 269 records, eleven trials were included in the meta-analysis using a random-effect model.
RESULTS: Coenzyme Q10 could significantly reduce Plaque Index (SMD, -0.64; CI, -1.03 to -0.26, P = .002; I2 = 85.7%), Bleeding Index (SMD, -1.05; CI, -1.70 to -0.41, P = .001; I2 = 89.5%), Pocket Depth (SMD, -0.96; CI, -1.35 to -0.58, P ˂ .001, I2 = 84.7%), clinical attachment level (SMD, -0.73; CI, -1.23 to -0.22, P = .005; I2 = 87.8%), and gingival index (SMD, -0.63; CI, -0.97 to -0.28, P = .001; I2 = 72.8%) in periodontitis. Subgroup analysis showed that coenzyme Q10 had a stronger reduction effect if administered intra-pocket rather than topical. Studies with high risk of bias reported a greater positive effect of coenzyme Q10 compared to studies with unclear risk.
CONCLUSIONS: Our findings encourage administration of coenzyme Q10 gel in periodontitis based on its meaningful effect on Plaque Index, Bleeding Index, gingival index, clinical attachment level and Pocket Depth. Future studies with better qualities are required for a better conclusion.