■甲基苯丙胺经常与酒精共同消费,然而,对视觉引导行为的综合影响尚未通过实验评估.这项研究研究了在模拟驾驶任务中是否可以准确检测和索引甲基苯丙胺和酒精引起的凝视行为变化,以建立与交通安全相关的特征模式。
■在一个随机的,安慰剂对照,交叉研究设计,急性口服甲基苯丙胺(0.42mg/kg)在有或没有低剂量酒精(目标血液酒精含量为0.04%)的情况下对驾驶过程中凝视行为的影响进行了评估.20名健康成年人(平均年龄29.5岁(SD±4.9),40%女性)完成了四个,在为期4周的实验范例中,使用SensoMotoricInstruments帽式眼动仪进行1小时模拟驱动器,同时进行眼睛监测。凝视熵测量用于量化视觉扫描效率,表示为注视转换熵和静止注视熵。固定,记录为持续时间(毫秒,ms)和每分钟速率(计数),在开车期间,在10分钟的垃圾箱中进行检查。驾驶性能通过横向位置的标准偏差进行评估,速度和转向可变性的标准偏差。
■甲基苯丙胺增加了固定的速度和持续时间,并在高速公路行驶中产生了较少分散但更无序的注视模式,同时保持了性能。酒精单独损害眼球运动控制和驾驶性能,即使消费水平远低于许多国际司法管辖区规定的法定限额。
■受甲基苯丙胺影响的驾驶员在驾驶过程中在有限的视觉范围内表现出低效的探索。因此,眼动追踪指标显示出由于使用精神活性物质而导致中毒的可能性。
UNASSIGNED: Methamphetamine is frequently co-consumed with alcohol, yet combined effects on visually guided behaviours have not been experimentally assessed. This
study examined whether methamphetamine and alcohol-induced changes in
gaze behaviour can be accurately detected and indexed during a simulated driving task to establish characteristic patterns relevant to traffic safety.
UNASSIGNED: In a randomised, placebo-controlled, cross-over
study design, the effects of acute oral methamphetamine (0.42 mg/kg) were assessed with and without low doses of alcohol (target 0.04% blood alcohol content) on
gaze behaviour during driving. Twenty healthy adults (mean age 29.5 years (SD ± 4.9), 40% female) completed four, 1-h simulated drives with simultaneous eye monitoring using the SensoMotoric Instruments cap-mounted eye tracker over a 4-week experimental paradigm.
Gaze entropy measures were used to quantify visual scanning efficiency, expressed as
gaze transition entropy and stationary
gaze entropy. Fixations, recorded as duration (milliseconds, ms) and rate (count) per minute, were examined in 10-min bins over the duration of the drive. Driving performance was assessed by the standard deviation of lateral position, standard deviation of speed and steering variability.
UNASSIGNED: Methamphetamine increased the rate and duration of fixations and produced a less dispersed but more disorganised pattern of gaze during highway driving while preserving performance. Alcohol alone impaired both oculomotor control and driving performance, even when consumed at levels well below the legal limit stipulated in many international jurisdictions.
UNASSIGNED: Methamphetamine-affected drivers display inefficient exploration in a limited visual range during driving. Eye-tracking metrics thus show potential for indexing intoxication due to psychoactive substance usage.