目的:评估女性不孕症患者进食频率与辅助生殖技术(ART)结局之间的关系。
方法:本队列研究于2022年2月至2024年1月在东京医科大学医院进行。总的来说,101名女性患者有不孕症,没有中风史,心脏病,癌症,或1型或2型糖尿病纳入本研究.从问卷中提取的因素包括人口统计信息,ART前和20岁时的用餐频率,吸烟状况,和酒精消费状况。其他因素数据,包括年龄,身体质量指数,抗苗勒管激素水平,和平价历史,是从医疗记录中收集的。评估的临床结果包括移植胚胎的数量,临床妊娠,正在怀孕,活产,和流产。
结果:在调整了潜在的混杂因素后,包括年龄,吸烟状况,酒精消费状况,身体质量指数,抗苗勒管激素水平,和平价历史,对ART结局进行多变量分析.根据每周吃早餐的频率将患者分为几组,午餐,还有晚餐.每周吃6-7次早餐的患者在通过ART怀孕的情况下,活产率更高,流产率更低。
结论:ART前每周吃6-7次早餐与ART后成功率增加相关。这凸显了常规早餐消费对优化ART结果的潜在重要性。
OBJECTIVE: To assess the relationship between meal consumption frequency and assisted reproductive technology (ART) outcomes among female patients with infertility.
METHODS: This cohort study was conducted from February 2022 to January 2024 at Tokyo Medical University Hospital. Overall, 101 female patients with infertility issues and without a history of stroke, heart disease, cancer, or type 1 or type 2 diabetes were enrolled in this study. The factors extracted from the questionnaire included demographic information, meal consumption frequency before ART and at 20 years of age, smoking status, and alcohol consumption status. Data on other factors, including age, body mass index, anti-Müllerian hormone level, and parity history, were collected from medical records. The assessed clinical outcomes included number of transplanted embryos, clinical pregnancies, ongoing pregnancies, live births, and miscarriages.
RESULTS: After adjusting for potential confounding factors, including age, smoking status, alcohol consumption status, body mass index, anti-Müllerian hormone level, and parity history, a multivariate analysis of ART outcomes was performed. Patients were categorized into groups based on the frequency of weekly consumption of breakfast, lunch, and dinner. Patients who consumed breakfast 6-7 times a week were significantly more likely to have higher rates of live birth and lower rates of miscarriage in pregnancies conceived through ART.
CONCLUSIONS: Consumption of breakfast 6-7 times a week before ART was associated with increased success rates following ART. This highlights the potential importance of regular breakfast consumption for optimizing ART outcomes.