单胚胎体外受精后,父母在第10周了解到怀了双胞胎,并有各种迹象表明可能发生了胚胎混淆。因此,受影响的夫妇表示迫切需要澄清考虑堕胎的父母身份。然而,产前检查结果要到怀孕14/15周才能获得.法律上,然后,医生必须声称孕妇的严重身体或精神困扰,以证明第十二周后堕胎是合理的。然而,缺乏遗传相关性可能会给父母带来严重的心理困扰,即使在第十二周之后也可以终止妊娠,这在这个案例研究中与跨学科团队的伦理一起讨论,legal,和医学考虑。对于侵入性关系测试,使用经典的短串联重复序列(STR)分析对未出生的绒毛膜绒毛样本(CVS)和推定父母的唾液样本进行了遗传分析。两个CVS剖面的完美匹配表明发生了不寻常的晚期双轴,为此,幸运的是,父母是可以确认的。据我们所知,这是关于辅助生殖技术(ART)后疑似胚胎混合的产前调查的第一份报告,父母身份应该是固定的。我们想提请注意这个不可思议的场景,未来随着ART引起的多胎妊娠的增加,这种情况可能会增加。
After in vitro fertilization with a single embryo, the parents learned about being pregnant with twins in the 10th week with various indications that an embryonic mix-up could have taken place. The affected couple thus expressed the urgent desire for a clarification of parenthood considering an abortion. However, the prenatal test results would not have been available until the 14/15th week of pregnancy. Legally, then, severe physical or mental distress of the pregnant woman must be claimed by physicians to justify an abortion after the twelfth week. However, a lack of genetic relatedness could lead to serious psychological distress for the parents, making a pregnancy termination possible even after the twelfth week, which is discussed in this
case study alongside the interdisciplinary team\'s ethical, legal, and medical considerations.For the invasive relationship testing, cultivated chorionic villi samples (CVS) from both unborn and saliva samples from the putative parents were genetically analyzed using classical short tandem repeats (STR) analysis. The perfect match of both CVS profiles suggested the occurrence of an unusual late twin shaft, for which, fortunately, parenthood could be confirmed. To our knowledge, this is the first report on a prenatal investigation of a suspected embryo mix-up after assisted reproductive technology (ART), in which parenthood should be fixed. We want to draw attention to this unthinkable scenario, which may increase in the future with ART-induced rising multiple pregnancies.