PDF(Pubmed)
Abstract：
The Endometrial Receptivity Array (ERA) is a revolutionary molecular diagnostic tool that determines the optimal timing for embryo transfer by analyzing the gene expression profile of endometrial tissue. This comprehensive review examines the significance and application of ERA in euploid embryo transfer cycles, where the implantation of embryos with the correct number of chromosomes is critical for achieving successful pregnancy outcomes. This review underscores its role in enhancing implantation rates and reducing pregnancy loss by assessing the evolution, methodology, clinical applications, efficacy, and challenges associated with ERA. Key findings highlight ERA\'s superior accuracy in identifying the window of implantation compared to traditional methods, resulting in improved clinical outcomes in assisted reproductive technology (ART) cycles. Despite its benefits, the review acknowledges challenges such as cost, accessibility, and the need for standardization. Recommendations for clinical practice emphasize the integration of ERA into routine ART protocols, comprehensive patient counseling, and the importance of multidisciplinary collaboration. The review outlines promising prospects, including technological advancements to make ERA more cost-effective, the development of refined gene expression profiles, and the potential integration with other emerging ART technologies. Further research directions include long-term studies on the outcomes of ERA-guided pregnancies and exploring its application in cases of recurrent implantation failure and unexplained infertility. Overall, ERA represents a significant advancement in reproductive medicine, offering a personalized approach to embryo transfer timing that can significantly improve the success rates of euploid embryo transfers.
摘要：
子宫内膜容受性阵列（ERA）是一种革命性的分子诊断工具，它通过分析子宫内膜组织的基因表达谱来确定胚胎移植的最佳时机。这篇综合综述了ERA在整倍体胚胎移植周期中的意义和应用。其中植入具有正确数量的染色体的胚胎对于实现成功的妊娠结局至关重要。这篇综述强调了它在提高植入率和通过评估进化减少妊娠损失中的作用。方法论，临床应用，功效,以及与ERA相关的挑战。与传统方法相比，ERA在识别植入窗口方面具有更高的准确性。改善辅助生殖技术（ART）周期的临床结局。尽管有好处,审查承认诸如成本、可访问性,以及标准化的需要。临床实践建议强调将ERA整合到常规ART方案中，全面的病人咨询，以及多学科合作的重要性。审查概述了有希望的前景，包括使ERA更具成本效益的技术进步，完善的基因表达谱的发展，以及与其他新兴ART技术的潜在集成。进一步的研究方向包括对ERA指导的妊娠结局的长期研究，并探索其在复发性植入失败和无法解释的不孕症病例中的应用。总的来说,ERA代表了生殖医学的重大进步，提供一种个性化的胚胎移植时机方法，可以显着提高整倍体胚胎移植的成功率。
