背景:核孔复合物(NPC)是复杂且动态的蛋白质结构,其跨越核膜并充当在细胞核和细胞质之间运输分子的看门人。NPC包含多达30种称为核孔蛋白(NUP)的不同蛋白质。然而,越来越多的研究表明,NPC在基因调控中起着重要作用,病毒感染,癌症,有丝分裂,遗传性疾病,肾脏疾病,免疫系统疾病,以及退化性神经和肌肉病变。
目的:在这篇综述中,介绍了NPCs的结构和功能。然后我们描述了NPCs各组分的生理和病理作用,为将来的临床应用提供了方向。
方法:本文综述了PubMed的相关文献。
结论:这篇综述总结了目前关于NPCs在人体生理和病理学中的意义的研究。强调NPC相关疾病的机制基础。
BACKGROUND: Nuclear pore complexes (NPCs) are sophisticated and dynamic protein structures that straddle the nuclear envelope and act as gatekeepers for transporting molecules between the nucleus and the cytoplasm. NPCs comprise up to 30 different proteins known as nucleoporins (NUPs). However, a growing body of research has suggested that NPCs play important roles in gene regulation, viral infections, cancer, mitosis, genetic diseases, kidney diseases, immune system diseases, and degenerative neurological and muscular pathologies.
OBJECTIVE: In this review, we introduce the structure and function of NPCs. Then We described the physiological and pathological effects of each component of NPCs which provide a direction for future clinical applications.
METHODS: The literatures from PubMed have been reviewed for this article.
CONCLUSIONS: This review summarizes current studies on the implications of NPCs in human physiology and pathology, highlighting the mechanistic underpinnings of NPC-associated diseases.