PDF(Pubmed)
Abstract：
The separation of genetic material from bulk cytoplasm has enabled the evolution of increasingly complex organisms, allowing for the development of sophisticated forms of life. However, this complexity has created new categories of dysfunction, including those related to the movement of material between cellular compartments. In eukaryotic cells, nucleocytoplasmic trafficking is a fundamental biological process, and cumulative disruptions to nuclear integrity and nucleocytoplasmic transport are detrimental to cell survival. This is particularly true in post-mitotic neurons, where nuclear pore injury and errors to nucleocytoplasmic trafficking are strongly associated with neurodegenerative disease. In this review, we summarize the current understanding of nuclear pore biology in physiological and pathological contexts and discuss potential therapeutic approaches for addressing nuclear pore injury and dysfunctional nucleocytoplasmic transport.
摘要：
遗传物质从大量细胞质中的分离使得越来越复杂的生物能够进化，允许复杂生命形式的发展。然而,这种复杂性创造了新的功能障碍类别，包括与细胞隔室之间的物质运动有关的那些。在真核细胞中,核质运输是一个基本的生物学过程，核完整性和核质运输的累积破坏对细胞存活有害。在有丝分裂后的神经元中尤其如此，其中核孔损伤和核质运输错误与神经退行性疾病密切相关。在这次审查中,我们总结了目前在生理和病理背景下对核孔生物学的理解，并讨论了解决核孔损伤和功能失调的核质转运的潜在治疗方法。
