PDF(Pubmed)
Abstract：
Heterochromatin and euchromatin form different spatial compartments in the interphase nucleus, with heterochromatin being localized mainly at the nuclear periphery. The mechanisms responsible for peripheral localization of heterochromatin are still not fully understood. The nuclear lamina and nuclear pore complexes were obvious candidates for the role of heterochromatin binders. This review is focused on recent studies showing that heterochromatin interactions with the nuclear lamina and nuclear pore complexes maintain its peripheral localization. Differences in chromatin interactions with the nuclear envelope in cell populations and in individual cells are also discussed.
摘要：
异染色质和常染色质在相间核中形成不同的空间区室，异染色质主要位于核外围。负责异染色质外周定位的机制仍未完全理解。核层和核孔复合物是异染色质粘合剂作用的明显候选者。这篇综述集中在最近的研究表明，异染色质与核层和核孔复合物的相互作用保持其外周定位。还讨论了细胞群体和单个细胞中染色质与核膜相互作用的差异。
