■与非西班牙裔白人相比,西班牙裔/拉丁美洲人接受慢性肾脏疾病最佳治疗的可能性较小。这对育龄妇女可能特别不利,因为慢性肾脏疾病会增加不孕的风险,月经不调,怀孕的损失。虽然这些产妇结局与晚期慢性肾脏疾病相关,其在早期慢性肾脏病中的发生尚不清楚.
■使用来自西班牙裔社区健康研究/拉丁美洲人研究的基线(2008-2011)和第二次研究访问(2014-2017)数据,我们回顾性评估了慢性肾脏病的患病率以及慢性肾脏病与自我报告的不孕症之间的关联,月经停止,子宫切除术,育龄期(18-45岁)的妇女和无法存活的妊娠丢失(妊娠少于24周)。
多变量调查逻辑回归分析确定了慢性肾脏病和单独结局之间的未调整和多变量调整的患病率比值比,置信区间为95%。
■包括2589名西班牙裔/拉丁裔女性(平均年龄=31.4岁),4.6%被认为患有慢性肾病。在调整后的分析中,患有慢性肾脏病的女性不孕症的几率没有显着增加(优势比=1.02,95%置信区间=0.42-2.49),月经停止(比值比=1.25,95%置信区间=0.52-3.04),或子宫切除术(比值比=1.17,95%置信区间=0.61-2.25)与无慢性肾脏疾病的患者相比。在患有慢性肾病的人中,基线访视后发生无存活妊娠丢失的校正几率增加(比值比=2.11,95%置信区间=0.63~7.02),但无统计学意义.
早期慢性肾脏病的存在并没有导致不孕的显著风险,月经停止,或无法怀孕。
西班牙裔社区健康研究/拉丁美洲人研究是一项基于人口的研究,涉及美国各地超过16,000名西班牙裔/拉丁美洲人。在这个群体中,我们评估了育龄妇女(18-45岁)的慢性肾脏疾病患病率以及肾脏疾病与不孕症之间的关联,月经停止,和无法存活的妊娠损失(妊娠24周之前发生的损失)。我们发现,肾脏病影响了20个育龄妇女中的1个,患有肾脏病的妇女更容易患肥胖症,糖尿病,和高血压。与没有肾病的人相比,肾脏疾病的存在并没有增加不孕的风险,月经停止,或无法怀孕。
Hispanic/Latino individuals are less likely to receive optimal treatment for chronic kidney disease than non-Hispanic whites. This may be particularly detrimental for women of reproductive age as chronic kidney disease increases risk for infertility, menstrual irregularities, and pregnancy loss. While these maternal outcomes have been associated with advanced chronic kidney disease, their occurrence in early chronic kidney disease is unclear.
Using baseline (2008-2011) and second
study visit (2014-2017) data from the Hispanic Community Health
Study/
Study of Latinos, we retrospectively assessed the prevalence of chronic kidney disease as well as the association between chronic kidney disease and self-reported infertility, cessation of menses, hysterectomy, and nonviable pregnancy loss (experienced at less than 24 weeks gestation) in women of reproductive age (18-45 years).
Multivariable survey logistic regression analyses determined the unadjusted and multivariable-adjusted prevalence odds ratios with 95% confidence intervals between chronic kidney disease and the separate outcomes.
Among 2589 Hispanic/Latino women included (mean age = 31.4 years), 4.6% were considered to have chronic kidney disease. In adjusted analyses, women with chronic kidney disease did not have a significantly increased odds of infertility (odds ratio = 1.02, 95% confidence interval = 0.42-2.49), cessation of menses (odds ratio = 1.25, 95% confidence interval = 0.52-3.04), or hysterectomy (odds ratio = 1.17, 95% confidence interval = 0.61-2.25) compared to those without chronic kidney disease. In those with chronic kidney disease, the adjusted odds of a nonviable pregnancy loss occurring after baseline visit were increased (odds ratio = 2.11, 95% confidence interval = 0.63-7.02) but not statistically significance.
The presence of early stage chronic kidney disease did not confer a significant risk of infertility, cessation of menses, or nonviable pregnancy loss.
The Hispanic Community Health
Study/
Study of Latinos is a population-based
study of over 16,000 Hispanic/Latino individuals throughout the United States. Within this cohort, we assessed the prevalence of chronic kidney disease in women of reproductive age (18–45 years old) and the associations between kidney disease and infertility, cessation of menses, and nonviable pregnancy loss (loss occurring before the 24th week of pregnancy). We found that kidney disease affected 1 in 20 women of reproductive age and those with kidney disease were more likely to have obesity, diabetes, and hypertension. Compared to those without kidney disease, the presence of kidney disease did not increase risk of infertility, cessation of menses, or nonviable pregnancy loss.