PDF(Pubmed)
Abstract：
UNASSIGNED: Thyroid-related hormones act to regulate metabolic pathways and blood pressure (BP). However, the relationship of TSH and peripheral thyroid hormones and the role of the hypothalamic-pituitary-thyroid axis on hypertension development is not fully understood. We assessed sex-specific associations of thyroid-related hormones with BP and hypertension in Hispanic/Latino adults followed for 6 years.
UNASSIGNED: We studied 1789 adults, ages 45 to 74, free of diabetes at baseline from a subcohort of the Hispanic Community Health Study/Study of Latinos. We assessed TSH, free T4 (FT4), T3, and various indicators of thyroid axis. Using multivariable linear and Poisson regression adjusted for survey design and confounding variables, we estimated a priori sex-specific associations of thyroid-related hormones with changes in BP and hypertension development.
UNASSIGNED: In men and women, TSH and TSH/FT4 ratios were associated with changes in diastolic BP and T3 with changes in pulse pressure and the development of hypertension from prehypertension. In men, a 1-SD increase in TSH [incident rate ratio (IRR) = 1.42; 95% confidence interval (CI): 1.15, 1.75] and TSH/FT4 ratio (IRR = 1.20; 95% CI: 1.07, 1.35) were positively associated with the development of hypertension from prehypertension while the TSH/FT4 ratio (IRR = 0.85; 95% CI: .72, 1.00) was protective in women. We observed sex-specific differences in associations of the T3/FT4 ratio and indices of pituitary sensitivity to thyroid hormones with changes in pulse pressure and hypertension development.
UNASSIGNED: Thyroid-related hormones are associated with sex-specific changes in BP and hypertension among Hispanic/Latino adults consistent with selected studies conducted in other populations. Mechanisms underlying associations of pituitary sensitivity to thyroid hormones with BP and hypertension development warrant further study.
UNASSIGNED: We studied 1789 adults, ages 45 to 74, free of diabetes at baseline from a subcohort of the Hispanic Community Health Study/Study of Latinos. We assessed TSH, free T4 (FT4), T3, and various indicators of thyroid axis. Using multivariable linear and Poisson regression adjusted for survey design and confounding variables, we estimated a priori sex-specific associations of thyroid-related hormones with changes in BP and hypertension development.
UNASSIGNED: In men and women, TSH and TSH/FT4 ratios were associated with changes in diastolic BP and T3 with changes in pulse pressure and the development of hypertension from prehypertension. In men, a 1-SD increase in TSH [incident rate ratio (IRR) = 1.42; 95% confidence interval (CI): 1.15, 1.75] and TSH/FT4 ratio (IRR = 1.20; 95% CI: 1.07, 1.35) were positively associated with the development of hypertension from prehypertension while the TSH/FT4 ratio (IRR = 0.85; 95% CI: .72, 1.00) was protective in women. We observed sex-specific differences in associations of the T3/FT4 ratio and indices of pituitary sensitivity to thyroid hormones with changes in pulse pressure and hypertension development.
UNASSIGNED: Thyroid-related hormones are associated with sex-specific changes in BP and hypertension among Hispanic/Latino adults consistent with selected studies conducted in other populations. Mechanisms underlying associations of pituitary sensitivity to thyroid hormones with BP and hypertension development warrant further study.
摘要：
■甲状腺相关激素调节代谢途径和血压（BP）。然而,TSH与外周甲状腺激素的关系以及下丘脑-垂体-甲状腺轴在高血压发展中的作用尚不完全清楚。我们评估了持续6年的西班牙裔/拉丁裔成年人甲状腺相关激素与血压和高血压的性别特异性关联。
■我们研究了1789名成年人，年龄45至74岁，基线时无糖尿病，来自西班牙裔社区健康研究/拉丁裔研究的一个子队列。我们评估了TSH,自由T4（FT4），T3和甲状腺轴的各种指标。使用多变量线性和泊松回归对测量设计和混杂变量进行调整，我们估计了甲状腺相关激素与血压和高血压发展变化的先验性别特异性关联.
■在男性和女性中，TSH和TSH/FT4比值与舒张压和T3的变化以及脉压的变化以及高血压前期的高血压发展有关。在男人中，TSH的1-SD升高[发生率比(IRR)=1.42;95%置信区间(CI):1.15,1.75]和TSH/FT4比值(IRR=1.20;95%CI:1.07,1.35)与高血压前期的发展呈正相关,而TSH/FT4比值(IRR=0.85;95%CI:0.72,1.00)对女性具有保护作用.我们观察了T3/FT4比率和垂体对甲状腺激素敏感性指数与脉压和高血压发展变化的相关性的性别差异。
在西班牙裔/拉丁裔成年人中，甲状腺相关激素与血压和高血压的性别特异性变化相关，这与在其他人群中进行的部分研究一致。垂体对甲状腺激素敏感性与BP和高血压发展相关的潜在机制需要进一步研究。
■我们研究了1789名成年人，年龄45至74岁，基线时无糖尿病，来自西班牙裔社区健康研究/拉丁裔研究的一个子队列。我们评估了TSH,自由T4（FT4），T3和甲状腺轴的各种指标。使用多变量线性和泊松回归对测量设计和混杂变量进行调整，我们估计了甲状腺相关激素与血压和高血压发展变化的先验性别特异性关联.
■在男性和女性中，TSH和TSH/FT4比值与舒张压和T3的变化以及脉压的变化以及高血压前期的高血压发展有关。在男人中，TSH的1-SD升高[发生率比(IRR)=1.42;95%置信区间(CI):1.15,1.75]和TSH/FT4比值(IRR=1.20;95%CI:1.07,1.35)与高血压前期的发展呈正相关,而TSH/FT4比值(IRR=0.85;95%CI:0.72,1.00)对女性具有保护作用.我们观察了T3/FT4比率和垂体对甲状腺激素敏感性指数与脉压和高血压发展变化的相关性的性别差异。
在西班牙裔/拉丁裔成年人中，甲状腺相关激素与血压和高血压的性别特异性变化相关，这与在其他人群中进行的部分研究一致。垂体对甲状腺激素敏感性与BP和高血压发展相关的潜在机制需要进一步研究。
