Abstract：
UNASSIGNED: Higher allostatic load (AL), a multi-system measure of physiological dysregulation considered a proxy for chronic stress exposure, is associated with poorer global cognition (GC) in older non-Hispanic white adults. However, evidence of these associations in middle-aged and older US-based Hispanic/Latino adults is limited.
UNASSIGNED: To examine associations of AL with level of cognition, performance in cognition 7 years later, and change in cognition over 7 years among middle-aged and older US-based Hispanic/Latino adults.
UNASSIGNED: We used data (n = 5,799, 45-74 years at baseline) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) and SOL-Investigation of Neurocognitive Aging (SOL-INCA). The AL score comprised 16 biomarkers representing cardiometabolic, glucose, cardiopulmonary, parasympathetic, and inflammatory systems (higher scores = greater dysregulation). Cognitive outcomes included GC and individual tests of verbal learning and memory, world fluency (WF), Digit Symbol Substitution (DSS), and Trail Making (Parts A & B). Survey-linear regressions assessed associations of AL with performance in cognition at baseline, 7 years later, and via 7-year cognitive change scores adjusting for sociodemographic characteristics, lifestyle factors, and depressive symptoms.
UNASSIGNED: Higher AL was associated with lower baseline performance in GC and WF; and lower 7-year follow-up performance in these same measures plus DSS and Trail Making Parts A & B. Higher AL was associated with more pronounced 7-year change (reduction) in GC and on WF and DSS tests.
UNASSIGNED: Findings extend previous evidence in predominantly older non-Hispanic white cohorts to show that AL is related to level of and change in GC (as well as WF and DSS) among middle-aged and older US-based Hispanic/Latino adults.
UNASSIGNED: To examine associations of AL with level of cognition, performance in cognition 7 years later, and change in cognition over 7 years among middle-aged and older US-based Hispanic/Latino adults.
UNASSIGNED: We used data (n = 5,799, 45-74 years at baseline) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) and SOL-Investigation of Neurocognitive Aging (SOL-INCA). The AL score comprised 16 biomarkers representing cardiometabolic, glucose, cardiopulmonary, parasympathetic, and inflammatory systems (higher scores = greater dysregulation). Cognitive outcomes included GC and individual tests of verbal learning and memory, world fluency (WF), Digit Symbol Substitution (DSS), and Trail Making (Parts A & B). Survey-linear regressions assessed associations of AL with performance in cognition at baseline, 7 years later, and via 7-year cognitive change scores adjusting for sociodemographic characteristics, lifestyle factors, and depressive symptoms.
UNASSIGNED: Higher AL was associated with lower baseline performance in GC and WF; and lower 7-year follow-up performance in these same measures plus DSS and Trail Making Parts A & B. Higher AL was associated with more pronounced 7-year change (reduction) in GC and on WF and DSS tests.
UNASSIGNED: Findings extend previous evidence in predominantly older non-Hispanic white cohorts to show that AL is related to level of and change in GC (as well as WF and DSS) among middle-aged and older US-based Hispanic/Latino adults.
摘要：
■较高的静载（AL），生理失调的多系统测量被认为是慢性压力暴露的替代指标，与老年非西班牙裔白人成年人较差的全球认知能力（GC）有关。然而,在美国中年和老年西班牙裔/拉丁裔成年人中,这些关联的证据有限.
■为了检查AL与认知水平的关联，7年后的认知表现，和认知的变化超过7年的中年和老年美国的西班牙裔/拉丁裔成年人。
■我们使用了来自西班牙裔社区健康研究/拉丁美洲人研究（HCHS/SOL）和SOL-神经认知衰老调查（SOL-INCA）的数据（基线时n=5,799，45-74年）。AL评分包括16个代表心脏代谢的生物标志物，葡萄糖，心肺,副交感神经,和炎症系统（更高的分数=更大的失调）。认知结果包括GC和口头学习和记忆的个人测试，世界流畅度（WF），数字符号替换(DSS),和跟踪制作（A和B部分）。调查线性回归评估了基线时AL与认知表现的关联，7年后,通过7年认知变化分数调整社会人口统计学特征，生活方式因素，和抑郁症状。
■较高的AL与GC和WF的基线性能较低相关；在这些相同的措施加上DSS和TrailMakingPartsA&B中，较低的7年随访性能较低。
■研究结果扩展了以前在主要是年龄较大的非西班牙裔白人队列中的证据，表明AL与中年和老年美国西班牙裔/拉丁裔成年人的GC（以及WF和DSS）水平和变化有关。
■为了检查AL与认知水平的关联，7年后的认知表现，和认知的变化超过7年的中年和老年美国的西班牙裔/拉丁裔成年人。
■我们使用了来自西班牙裔社区健康研究/拉丁美洲人研究（HCHS/SOL）和SOL-神经认知衰老调查（SOL-INCA）的数据（基线时n=5,799，45-74年）。AL评分包括16个代表心脏代谢的生物标志物，葡萄糖，心肺,副交感神经,和炎症系统（更高的分数=更大的失调）。认知结果包括GC和口头学习和记忆的个人测试，世界流畅度（WF），数字符号替换(DSS),和跟踪制作（A和B部分）。调查线性回归评估了基线时AL与认知表现的关联，7年后,通过7年认知变化分数调整社会人口统计学特征，生活方式因素，和抑郁症状。
■较高的AL与GC和WF的基线性能较低相关；在这些相同的措施加上DSS和TrailMakingPartsA&B中，较低的7年随访性能较低。
■研究结果扩展了以前在主要是年龄较大的非西班牙裔白人队列中的证据，表明AL与中年和老年美国西班牙裔/拉丁裔成年人的GC（以及WF和DSS）水平和变化有关。
