神经血管耦合(NVC)是脑血流量(CBF)的扰动,以满足各种水平的神经活动引起的不同代谢需求。NVC可以通过经颅多普勒超声(TCD)进行评估,使用任务激活协议,但由于研究之间的方法异质性很大,阻碍交叉研究比较。因此,这篇综述旨在总结和比较基于TCD的健康NVC评估的可用方法。Medline(Ovid),Scopus,WebofScience,EMBASE(Ovid)和CINAHL使用预定义的搜索策略进行搜索(PROSPERO:CRD42019153228),生成6006篇文章。纳入的研究包含基于TCD的健康成人NVC评估。使用清单评估研究质量,研究结果是以叙述方式综合的。76项研究(2697名参与者)符合审查标准。所使用的参与者位置存在显著的异质性(例如,坐着vs仰卧),在TCD设备中,和血管被声波照射(如中部,后部,和大脑前动脉)。较大,更重要的是,基于TCD的NVC响应通常包括就座位置,基线持续时间>一分钟,外来光线控制,和实施先前验证的协议。此外,互补,组合位置,血管超声和刺激型方案与更显著的NVC结果相关.这里有详细的建议,但是需要对患者人群进行进一步调查,用于进一步优化基于TCD的NVC评估。
Neurovascular coupling (NVC) is the perturbation of cerebral blood flow (CBF) to meet varying metabolic demands induced by various levels of neural activity. NVC may be assessed by Transcranial Doppler ultrasonography (TCD), using task activation protocols, but with significant methodological heterogeneity between studies, hindering cross-study comparisons. Therefore, this review aimed to summarise and compare available methods for TCD-based
healthy NVC assessments. Medline (Ovid), Scopus, Web of Science, EMBASE (Ovid) and CINAHL were searched using a predefined search strategy (PROSPERO: CRD42019153228), generating 6006 articles. Included studies contained TCD-based assessments of NVC in
healthy adults. Study quality was assessed using a checklist, and findings were synthesised narratively. 76 studies (2697 participants) met the review criteria. There was significant heterogeneity in the participant position used (e.g., seated vs supine), in TCD equipment, and vessel insonated (e.g. middle, posterior, and anterior cerebral arteries). Larger, more significant, TCD-based NVC responses typically included a seated position, baseline durations >one-minute, extraneous light control, and implementation of previously validated protocols. In addition, complementary, combined position, vessel insonated and stimulation type protocols were associated with more significant NVC results. Recommendations are detailed here, but further investigation is required in patient populations, for further optimisation of TCD-based NVC assessments.