DNA折纸是一种尖端的纳米技术方法,可创建精确而详细的2D和3D纳米结构。DNA折纸的关键特征是它是如何产生的,这使得能够精确控制其大小和形状。生物相容性,可瞄准性,可编程性,和稳定性是进一步的优势,使其成为各种应用的潜在有益技术。通过DNA折纸的最新发展,可以对特定疾病相关触发因素和微环境做出精确反应的复杂可编程纳米医学和纳米设备的临床前研究已经成为可能。这些刺激,它们是目标疾病的内源性物质,包括蛋白质上调,pH值,氧化还原状态,小化学品。传统上,肿瘤学一直是过去和当前有关该主题的大多数研究的重点。因此,在这次全面审查中,我们深入到DNA折纸的复杂世界,探索其定义特征和能力。这篇综述涵盖了DNA折纸的基本特征,将DNA折纸靶向细胞,细胞摄取,和亚细胞定位。在整个审查过程中,我们强调阐明了这样一个治疗平台的必要性,特别是在解决心血管疾病(CVD)的复杂性。此外,我们探索DNA折纸技术的巨大潜力,设想其在CVD治疗领域及其他领域的有希望的作用。
DNA origami is a cutting-edge nanotechnology approach that creates precise and detailed 2D and 3D nanostructures. The crucial feature of DNA origami is how it is created, which enables precise control over its size and shape. Biocompatibility, targetability, programmability, and stability are further advantages that make it a potentially beneficial technique for a variety of applications. The preclinical studies of sophisticated programmable nanomedicines and nanodevices that can precisely respond to particular disease-associated triggers and microenvironments have been made possible by recent developments in DNA origami. These stimuli, which are endogenous to the targeted disorders, include protein upregulation, pH, redox status, and small chemicals. Oncology has traditionally been the focus of the majority of past and current research on this subject. Therefore, in this comprehensive
review, we delve into the intricate world of DNA origami, exploring its defining features and capabilities. This
review covers the fundamental characteristics of DNA origami, targeting DNA origami to cells, cellular uptake, and subcellular localization. Throughout the
review, we emphasised on elucidating the imperative for such a therapeutic platform, especially in addressing the complexities of cardiovascular disease (CVD). Moreover, we explore the vast potential inherent in DNA origami technology, envisioning its promising role in the realm of CVD treatment and beyond.