抑制反式翻译的抗生素阻断 EF - Tu 与 tmRNA 但不与 tRNA 的结合。
关键词: EF-Tu KKL-55 antibiotic elfamycin protein synthesis tRNA tmRNA trans-translation
Mesh : Peptide Elongation Factor Tu / genetics Peptide Elongation Factors / genetics Anti-Bacterial Agents / pharmacology RNA-Binding Proteins / genetics Protein Biosynthesis RNA, Bacterial / genetics RNA, Transfer / metabolism
来 源:
DOI:10.1128/mbio.01461-23
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