PDF(Pubmed)
Abstract：
Background: Cumulative exposure to violence can change the regulation of epigenetic and physiological markers. Although violence has been associated with accelerated cellular aging, little is known about associations with cardiac autonomic activity.Objective: The current study aimed to investigate the relationship of exposure to community and domestic violence (CDV) with vagal activity and epigenetic aging acceleration.Methods: A total of 86 adolescents (57% female) were evaluated and interviewed at two time-points in São Gonçalo (2014-2019), a Brazilian city with high levels of violence. Exposure to CDV was assessed in both time-points. GrimAge acceleration was calculated from saliva DNA methylation using Infinium HumanMethylation450K (Illumina) collected in the first assessment. Heart rate variability (HRV) was collected during two stress tasks at the second assessment.Results: The exposure to violence witnessed or directly experienced at home and in the community increased significantly (t = 4.87, p < .01) across two-time points, and males had reported higher violence exposure (t = 2.06, p = .043). Violence at 1st assessment was significantly associated with GrimAge acceleration (B = .039, p value = .043). Violence at both assessments were associated with HRV measured during the narration of the worst trauma (traumaHRV) (B = .009, p value = .039, and B = .007, p value = .024, 1st and 2nd assessment respectively). GrimAge acceleration was significantly associated with traumaHRV (B = .043, p value = .049), and HRV measured during a 3D roller coaster video (B = .061, p value = .024).Conclusions: We found relevant evidence that experiencing violence during adolescence is associated with epigenetic aging and stress-related vagal activity. Understanding these factors during this period could contribute to the development of early interventions for health promotion.HIGHLIGHTS Higher exposure to Community and domestic violence is associated with increased GrimAge acceleration.Higher GrimAge acceleration is associated with increased stress-related vagal activity.Exposure to community and domestic violence increased significantly over time.
摘要：
背景：暴力累积暴露可以改变表观遗传和生理标记的调节。尽管暴力与加速的细胞衰老有关，人们对心脏自主神经活动的关系知之甚少。目的：本研究旨在探讨社区和家庭暴力（CDV）暴露与迷走神经活动和表观遗传衰老加速的关系。方法：在圣冈萨洛（2014-2019年）的两个时间点对86名青少年（57％为女性）进行了评估和访谈，一个暴力程度较高的巴西城市。在两个时间点评估对CDV的暴露。使用在第一次评估中收集的InfiniumHumanMethomethylation450K(Illumina)从唾液DNA甲基化计算GrimAge加速度。在第二次评估中，在两次压力任务期间收集心率变异性（HRV）。结果：在两个时间点，在家庭和社区目睹或直接经历的暴力暴露显着增加（t=4.87，p<0.01），男性报告较高的暴力暴露（t=2.06，p=0.043）。第一次评估时的暴力与GrimAge加速度显着相关（B=.039，p值=.043）。两种评估中的暴力均与最坏创伤（trainaHRV）叙述期间测得的HRV相关（B=.009，p值=.039，B=.007，p值=.024，第1和第2次评估）。GrimAge加速度与创伤HRV显著相关(B=.043，p值=.049)，以及在3D过山车视频期间测量的HRV(B=.061,p值=.024)。结论：我们发现相关证据表明，青春期经历暴力与表观遗传衰老和压力相关的迷走神经活动有关。在此期间了解这些因素可能有助于制定促进健康的早期干预措施。突出显示较高的社区和家庭暴力暴露与增加的GrimAge加速度相关。较高的GrimAge加速度与增加的压力相关的迷走神经活动有关。随着时间的推移，社区和家庭暴力的风险显著增加。
