目的:本研究的目的是探索在人们日益关注老龄化人口和相关疾病的情况下,坚持美国心脏协会更新的生命基础8(LE8)评分在延缓生物衰老方面的潜力。
方法:使用2005-2010年和2015-2018年的国家健康和营养检查调查数据对18261名成年人(≥20岁)进行了检查。LE8包括8个组件,涵盖健康行为和因素。生物衰老的加速被定义为生物/表型年龄超过实际年龄,通过使用临床生物标志物进行评估。通过回归分析探索LE8评分与生物衰老之间的关联。
结果:LE8评分每增加10分,生物学年龄减少1.19岁,表型年龄减少1.63岁。与具有低CVH的个体相比,具有高心血管健康(CVH)的个体根据生物年龄加速衰老的风险降低了90%,并且根据表型年龄降低了81%。基于Bootstrap的模型估计和加权分位数和回归表明,健康因素,尤其是血糖,对延缓衰老有很大影响。吸烟与生物衰老之间的关联似乎取决于所使用的衰老定义。在所有亚组中,LE8始终与生物衰老呈负相关,尽管观察到的相互作用。三个敏感性分析证实了我们结论的稳健性。
结论:较高的CVH与较低的生物衰老风险相关。在人口统计学中保持升高的LE8水平,不管心血管病史,建议延缓衰老,促进健康衰老,对初级卫生保健有重大影响。
OBJECTIVE: The aim of this study was to explore the potential of adhering to the American Heart Association\'s updated Life\'s Essential 8 (LE8) scores in delaying biological aging amid growing concerns about aging populations and related diseases.
METHODS: A total of 18 261 adults (≥ 20 years old) were examined using National Health and Nutrition Examination Survey data from 2005-2010 and 2015-2018. The LE8 includes 8 components, covering health behaviors and factors. Acceleration of biological aging was defined as an excess of biological/phenotypic age over chronological age, assessed by using clinical biomarkers. The association between LE8 score and biological aging was explored through regression analyses.
RESULTS: Each 10-point increase in LE8 scores was associated with a 1.19-year decrease in biological age and a 1.63-year decrease in phenotypic age. Individuals with high cardiovascular health (CVH) had a 90% reduction in their risk of accelerated aging based on biological age and an 81% reduction based on phenotypic age compared with individuals with low CVH. Bootstrap-based model estimates and weighted quantile sum regression suggested that health factors, particularly blood glucose, had strong impact on delaying aging. The association between smoking and biological aging seemed to differ depending on the definition of aging used. Among all subgroups, LE8 consistently correlated negatively with biological aging, despite observed interactions. Three sensitivity analyses confirmed the robustness of our conclusions.
CONCLUSIONS: A higher CVH is associated with a lower risk of biological aging. Maintaining elevated LE8 levels across demographics, regardless of cardiovascular history, is recommended to delay aging and promote healthy aging, with significant implications for primary health care.