来自古代动物的单结构域抗体作为 SARS - CoV - 2 和其他冠状病毒的广泛中和剂。
关键词: γ , Gamma δ , Delta ACE2, Angiotensin-converting enzyme 2 ADCC, Antibody-dependent cell-mediated cytotoxicity ADCP, Antibody-dependent cellular phagocytosis ADE, Antibody-dependent enhancement Alb, Albumin Bat-SL-CoV, Bat SARS-like coronavirus Broad neutralization CDC, Complement-dependent cytotoxicity CDR, Complementarity-determining region CH, Constant domain of antibody heavy chain CHO, Chinese hamster ovary CL, Constant domain of antibody light chain CNAR, Constant domain of immunoglobulin new antigen receptor COVID-19 COVID-19, Coronavirus disease 2019 Cryo-EM, Cryogenic electron microscopy Cu, Copper DNA, Deoxyribonucleic acid DPP4, Dipeptidyl peptidase 4 E, Envelope EC50, Half-maximal effective concentration FDA, The United States Food and Drug Administration Fab, Antigen-binding fragment Fc, Crystallisable fragment FcR, Crystallisable fragment receptor Fig., Figure HCoV, Human coronavirus HIV, Human immunodeficiency virus HR, Heptad repeat HRP, Horseradish peroxidase HV, Hypervariable region IC50, Half-maximal inhibitory concentration Ig, Immunoglobulin IgNAR, Immunoglobulin new antigen receptor KD, Equilibrium dissociation constant L, Litre LRT, Lower respiratory tract M, Membrane MERS, Middle East respiratory syndrome MERS-CoV, Middle East respiratory syndrome coronavirus N, Nucleocapsid ND50, 50% neutralizing dose NTD, N-terminal domain Nb, Nanobody PCR, Polymerase chain reaction PEG, Polyethylene glycol RBD, Receptor-binding domain RBM, Receptor-binding motif RNA, Ribonucleic acid S, Spike SARS, Severe acute respiratory syndrome SARS-CoV, Severe acute respiratory syndrome coronavirus SARS-CoV-2 mutation SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SPAAC, Strain-promoted azide-alkyne cycloaddition Single-domain antibody Spike protein TMPRSS2, Transmembrane serine protease 2 Therapeutic URT, Upper respiratory tract VH, Variable domain of antibody heavy chain VHH, Variable domain of camelid heavy-chain only antibody VL, Variable domain of antibody light chain VNAR, Variable domain of immunoglobulin new antigen receptor WHO, World Health Organization cDNA, Complementary deoxyribonucleic acid dpi, Days' post infection g, Gram kDa, Kilodalton koff, Dissociation rate constant mAb, Monoclonal antibody mRNA, Messenger ribonucleic acid nM, Nanomolar pM, Picomolar scFv, Single-chain variable fragment sdAb, Single-domain antibody ß, Beta α, Alpha
来 源:
DOI:10.1016/j.bea.2022.100054
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