Abstract：
The Dishevelled gene was first identified in Drosophila mutants with disoriented hair and bristle polarity and subsequent work has now demonstrated its importance in critical and diverse aspects of biology. Since those early discoveries, Dishevelled has been shown to coordinate a plethora of developmental and cellular processes that range from controlling cell polarity during gastrulation to partnering with chromatin modifying enzymes to regulate histone methylation at genomic loci. While the role of DVL in development is well-respected and the cytosolic function of DVL has been studied more extensively, its nuclear role continues to remain murky. In this review we highlight some of the seminal discoveries that have contributed to the field, but the primary focus is to discuss recent advances with respect to the nuclear role of Dishevelled. This nuclear function of Dishevelled is a dimension which is proving to be increasingly important yet remains enigmatic.
摘要：
Dishevelled基因最初是在果蝇突变体中发现的，该突变体具有迷失方向的毛发和刷毛极性，随后的工作现已证明其在生物学的关键和各个方面的重要性。自从那些早期发现以来，已显示出不态可协调过多的发育和细胞过程，范围从控制原肠胚形成过程中的细胞极性到与染色质修饰酶合作以调节基因组位点的组蛋白甲基化。虽然DVL在发育中的作用受到广泛尊重，DVL的胞浆功能也得到了更广泛的研究，它的核作用仍然模糊。在这篇评论中，我们重点介绍了对该领域做出贡献的一些开创性发现，但主要的重点是讨论有关Dishevelled核作用的最新进展。Dishevelled的这种核功能是一个被证明越来越重要的维度，但仍然是神秘的。
