癌症是一种多层面和复杂的疾病,其特征在于细胞增殖的不受控速率及其扩散和攻击其他器官的能力。新出现的数据表明几种途径和分子靶标参与癌症进展。其中,Wnt信号通路在癌症的发生和发展过程中具有重要作用.不均匀(DVL)作用于规范和非规范Wnt通路的分支点。DVL不仅在细胞质中发挥作用,使β-连环蛋白的破坏复合物失活,而且还被转运到细胞核中以影响靶基因的转录。现有数据显示,DVL的表达水平在各种癌症的细胞和临床标本中增加,认为它可能具有致癌作用。DVL促进细胞侵袭,迁移,细胞周期,生存,扩散,3D-球体形成,stemness,和上皮间质转化(EMT),并抑制细胞凋亡。较高的DVL水平与癌症患者的临床病理特征有关,包括淋巴结转移,肿瘤分级,组织学类型,和年龄。此外,较高的DVL水平可能是癌症诊断和预后的有前途的生物标志物,也可能是癌症化疗对甲氨蝶呤耐药的介质,紫杉醇,和5-氟尿嘧啶.本研究旨在探讨DVL在癌症发病中的潜在分子机制,探讨其在癌症诊断和预后中的重要性以及作为癌症化疗介质的作用。
Cancer is a multifaceted and complex disorder characterized by uncontrolled rates of cell proliferation and its ability to spread and attack other organs. Emerging data indicated several pathways and molecular targets are engaged in cancer progression. Among them, the Wnt signaling pathway was shown to have a crucial role in cancer onset and progression.
Dishevelled (DVL) acts in a branch point of canonical and non-canonical Wnt pathway. DVL not only acts in the cytoplasm to inactivate the destruction complex of β-catenin but is also transported into the nucleus to affect the transcription of target genes. Available data revealed that the expression levels of DVL increased in cell and clinical specimens of various cancers, proposing that it may have an oncogenic role. DVL promoted cell invasion, migration, cell cycle, survival, proliferation, 3D-spheroid formation, stemness, and epithelial mesenchymal transition (EMT) and it suppressed cell apoptosis. The higher levels of DVL is associated with the clinicopathological characteristic of cancer-affected patients, including lymph node metastasis, tumor grade, histological type, and age. In addition, the higher levels of DVL could be a promising diagnostic and prognostic biomarker in cancer as well as it could be a mediator in cancer chemoresistance to Methotrexate, paclitaxel, and 5-fluorouracil. This study aimed to investigate the underlying molecular mechanism of DVL in cancer pathogenesis as well as to explore its importance in cancer diagnosis and prognosis as well as its role as a mediator in cancer chemotherapy.