使用对乙酰氨基酚肝毒性模型进行机理研究的建议以及如何避免常见的陷阱。
关键词: AIF, apoptosis-inducing factor AMPK, AMP-activated protein kinase APAP, acetaminophen ARE, antioxidant response element ATG, autophagy-related genes Acetaminophen hepatotoxicity Apoptosis Autophagy BSO, buthionine sulfoximine CAD, caspase-activated DNase CYP, cytochrome P450 enzymes DAMPs, damage-associated molecular patterns DMSO, dimethylsulfoxide Drug metabolism EndoG, endonuclease G FSP1, ferroptosis suppressing protein 1 Ferroptosis GPX4, glutathione peroxidase 4 GSH, glutathione GSSG, glutathione disulfide Gclc, glutamate–cysteine ligase catalytic subunit Gclm, glutamate–cysteine ligase modifier subunit HMGB1, high mobility group box protein 1 HNE, 4-hydroxynonenal Innate immunity JNK, c-jun N-terminal kinase KEAP1, Kelch-like ECH-associated protein 1 LAMP, lysosomal-associated membrane protein LC3, light chain 3 LOOH, lipid hydroperoxides LPO, lipid peroxidation MAP kinase, mitogen activated protein kinase MCP-1, monocyte chemoattractant protein-1 MDA, malondialdehyde MPT, mitochondrial permeability transition Mitochondria MnSOD, manganese superoxide dismutase NAC, N-acetylcysteine NAPQI, N-acetyl-p-benzoquinone imine NF-κB, nuclear factor κB NQO1, NAD(P)H:quinone oxidoreductase 1 NRF2 NRF2, nuclear factor erythroid 2-related factor 2 PUFAs, polyunsaturated fatty acids ROS, reactive oxygen species SMAC/DIABLO, second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI TLR, toll like receptor TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling UGT, UDP-glucuronosyltransferases mTORC1, mammalian target of rapamycin complex 1
来 源:
DOI:10.1016/j.apsb.2021.09.023
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