未经证实:中风是一种神经系统疾病,其特征是由于血管阻塞导致大脑供氧减少后脑组织受损。据报道,80%的中风病例被归类为脑梗塞,这种情况的发病率随着年龄的增长而增加。在这里,我们比较了韩国白参(WG)和韩国红参(RG)提取物(WGex和RGex,分别)在缺血性中风小鼠模型中,并证实了潜在的作用机制。
未授权:在大脑中动脉闭塞(MCAO)前1小时,对小鼠口服WGex或RGex,2小时;MCAO诱导后24小时测量梗死面积的大小。然后,评估神经功能缺损评分,并比较两种提取物的疗效.最后,它们的作用机制通过组织染色和蛋白质定量得到证实.
未经证实:在MCAO诱导的缺血性中风小鼠模型中,WGex和RGex在皮质区域显示出神经保护作用,RGex的疗效优于WGex。人参皂苷Rg1,一种代表性的指示物质,不参与介导WGex和RGex的作用。
UNASSIGNED:WGex和RGex可以减轻缺血/再灌注引起的脑损伤,RGex显示出更有效的效果。在1,000毫克/千克体重时,只有RGex减少脑梗塞和水肿,抗炎和抗凋亡途径都参与介导这些作用。
UNASSIGNED: Stroke is a neurological disorder characterized by brain tissue damage following a decrease in oxygen supply to brain due to blocked blood vessels. Reportedly, 80% of all stroke cases are classified as cerebral infarction, and the incidence rate of this condition increases with age. Herein, we compared the efficacies of Korean White ginseng (WG) and Korean Red Ginseng (RG) extracts (WGex and RGex, respectively) in an ischemic stroke mouse model and confirmed the underlying mechanisms of action.
UNASSIGNED: Mice were orally administered WGex or RGex 1 h before middle cerebral artery occlusion (MCAO), for 2 h; the size of the infarct area was measured 24 h after MCAO induction. Then, the neurological deficit score was evaluated and the efficacies of the two extracts were compared. Finally, their mechanisms of action were confirmed with tissue staining and protein quantification.
UNASSIGNED: In the MCAO-induced ischemic stroke mouse model, WGex and RGex showed neuroprotective effects in the cortical region, with RGex demonstrating superior efficacy than WGex. Ginsenoside Rg1, a representative indicator substance, was not involved in mediating the effects of WGex and RGex.
UNASSIGNED: WGex and RGex could alleviate the brain injury caused by ischemia/reperfusion, with RGex showing a more potent effect. At 1,000 mg/kg body weight, only RGex reduced cerebral infarction and edema, and both anti-inflammatory and anti-apoptotic pathways were involved in mediating these effects.