心血管疾病中一氧化氮合酶抑制和氧化应激: 可能的治疗靶点?
关键词: 6-pyruvoyl tetrahydropterin synthase 7,8-dihydroneopterin 30 triphosphate 8-Oxoguanine DNA glycosylase ADMA AF AGXT2 AP-1 ARE AT ApoE-KO AscH(−) BH(3) BH(4) CAAs CAT CATs CR CV CaM Cardiovascular disease DDAHs DHFR DHPR DM DMA DMGV DNTP ERK FAD FMN FOS FOXO Finkel–Biskis–Jinkins osteosarcoma Free radicals GP GPx GSH GTP GTP cyclohydrolase 1 GTP-CH HIF HSP JNK LDL LTL MAO MAPK MDA MT N(G)-monomethyl-l-arginine N-nitro-l-arginine N-omega-hydroxy-l-arginine NADPH NADPH oxidase NF-κB NO NO inhibitors NO synthases NOHA NOX NTPH Nrf2 OGG1 OS PAH PCD PRMT PTPS Prx RNS ROS Ref-1 S-adenosyl-l-homocysteine S-adenosyl-l-methionine SAH SAM SDMA SOD SR TH TocH Trx UA activator protein 1 alanine-glyoxylate aminotransferase 2 angiotensin antioxidant response element apolipoprotein E knockout ascorbate anion asymmetric dimethylarginine atrial fibrillation c-Jun N-terminal kinase calmodulin carbonyl reductase cardiovascular catalases cationic amino acid transporters cationic amino acids diabetes mellitus dihydrofolate reductase dihydropteridine reductase dimethylamines dimethylarginine dimethylaminohydrolases eGFR estimated glomerular filtration rate extracellular signal-regulated kinase flavin adenine dinucleotide flavin mononucleotide forkhead protein glutathione glutathione peroxidases glutathioneperoxidase guanosine triphosphate heat shock protein hypoxia-inducible factor l-Arg l-NMMA l-NNA l-arginine leukocyte telomere length low-density lipoprotein malondialdehyde metallothionein mitogen-activated protein kinase monoamine oxidase neuronal tryptophan hydroxylase nicotinamide dinucleotide phosphate nitric oxide nuclear factor erythroid 2-related factor 2 nuclear factor κB oxidative stress peroxyredoxin phenylalanine hydroxylase protein arginine methyl transferase pterin-4a-carbinolamine dehydratase reactive nitrogen species reactive oxygen species redox factor-1 sepiapterin reductase siRNAs small interfering ribonucleic acids superoxide dismutase symmetric dimethylarginine tHcy tetrahydrobiopterin thioredoxin tocopherol total plasma homocysteine trihydrobiopterin radical tyrosine hydroxylase uric acid y+L AA y+LAT transporters α-keto-δ-(N(G),N(G)-dimethylguanidino)valeric acid
Mesh : Animals Cardiovascular Diseases / drug therapy enzymology metabolism Enzyme Inhibitors / pharmacology therapeutic use Humans Nitric Oxide / metabolism Nitric Oxide Synthase / antagonists & inhibitors metabolism Oxidative Stress / drug effects
来 源:
DOI:10.1016/j.pharmthera.2013.07.004
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