背景:超声心动图(ECHO)是一种引起儿童急性应激的非手术方法。恐惧,焦虑,儿童血压和心率的波动可能导致超声心动图测量结果的改变。虚拟现实儿科制剂应用研究不足,特别是在超声心动图程序的背景下,强调了针对儿科患者进行其他研究的必要性。本研究旨在评估为ECHO明确定制的虚拟现实应用对儿童氧化应激水平的影响。
方法:这是一个前瞻性的,随机化,对照实验研究。在2019年6月至8月的3个月内,在儿科心脏病学门诊预约的7至12岁的48名儿童(实验/24,对照/24)参加了该研究。血液分析显示溶血的参与者被消除,该研究共有37名儿童完成:16名儿童在实验中,21名儿童在对照中。对样本充足性进行了事后电源分析,该研究的功率为0.99。为研究准备了3D胶片,并在操作前将其应用于实验组。所有儿童的氧化应激水平(皮质醇,丙二醛,ECHO后检查一氧化氮)和谷胱甘肽水平。
结果:应用3D的实验组的应激激素皮质醇和丙二醛水平低于对照组。作为另一个重要的抗应激抗氧化因子,实验组谷胱甘肽水平较对照组升高(P<0.05)。
结论:研究表明,用于制备ECHO的3D胶片降低了与心脏风险相关的压力参数,并可能影响ECHO测量。同时,该研究还证明了通过增加抗应激因子来制备3D薄膜的积极作用。
BACKGROUND: Echocardiography (ECHO) is a nonprocedure that causes acute stress in children. Fear, anxiety, and fluctuations in children\'s blood pressure and heart rate can potentially lead to alterations in echocardiographic measurements. The insufficient research on virtual reality pediatric preparation applications, particularly in the context of echocardiographic procedures, underscores the necessity for additional studies focusing on pediatric patients. This study sought to assess the impact of virtual reality applications tailored explicitly for ECHO on children\'s oxidative stress levels.
METHODS: This was a prospective, randomized, controlled experimental study. Forty-eight children (experimental/24, control/24) aged 7 to 12 years who had an ECHO appointment in the pediatric cardiology outpatient clinic in the 3 months from June to August 2019 participated in the study. Participants whose blood analyses showed hemolysis were eliminated, and the study was completed with 37 children in total: 16 children in the experiment and 21 children in the control. Post hoc power analysis was performed for sample adequacy, and the power of the study was found to be 0.99. A 3D film was prepared for the research and applied to the experimental group before the procedure. All children\'s oxidative stress levels (cortisol,
malondialdehyde, nitric oxide) and glutathione levels were checked after ECHO.
RESULTS: The stress hormone cortisol and
malondialdehyde levels were lower in the 3D-applied experimental group than in the control group. As another crucial anti-stress antioxidant factor, glutathione level increased in the experimental group compared to the control group (P < .05).
CONCLUSIONS: The research revealed that the 3D film used to prepare ECHO reduces the stress parameters associated with heart risk and may affect the ECHO measurements. At the same time, the study also proved the positive effect of 3D film preparation by increasing the anti-stress factor.