背景:皮质视觉障碍(CVI)是由于视觉皮层或其传入的损害而导致的视觉功能的严重丧失,通常是由于出生时缺氧造成的。它是儿童视力丧失的主要原因之一,它通常是永久性的。
目的:一些研究表明,在接受良好控制的心理物理任务训练的成年人中,视力恢复有限,在晚年获得CVI后。其他研究表明,接受视力训练的儿童有所改善。然而,对于大量在出生时获得CVI但在儿童时期没有接受正规治疗的患者的前景知之甚少.
方法:我们,因此,对一名CVI患者在皮质损伤发作后很久(18岁)进行了原则验证研究,为了测试训练速度,使用先前已证明在成人中成功的方案进行视力康复的有效性和普遍性。病人在家里和实验室接受了训练,在一项心理物理任务中,需要区分盲场中呈现的复杂运动刺激。训练前后评估视觉功能,使用周边测量,以及一系列心理物理测试。
结果:患者在训练任务上表现出显著的快速改善,在11个会话的范围内,性能从机会到80%正确。经过进一步的培训,对于未经训练的刺激和视觉敏感度的周边测量,视力得到改善。一些,但不是全部,这些性能增益在一年后重新测试时保留。
结论:这些结果表明,现有的视力康复计划对年轻时获得CVI的成年患者非常有效。大样本量的验证至关重要,未来的工作也应该集中在提高这些项目对年轻患者的可用性和可及性上.
BACKGROUND: Cortical visual impairment (CVI) is a severe loss of visual function caused by damage to the visual cortex or its afferents, often as a consequence of hypoxic insults during birth. It is one of the leading causes of vision loss in children, and it is most often permanent.
OBJECTIVE: Several studies have demonstrated limited vision restoration in adults who trained on well-controlled psychophysical tasks, after acquiring CVI late in life. Other studies have shown improvements in children who underwent vision training. However, little is known about the prospects for the large number of patients who acquired CVI at birth but received no formal therapy as children.
METHODS: We, therefore, conducted a proof-of-principle study in one CVI patient long after the onset of cortical damage (age 18), to test the training speed, efficacy and generalizability of vision rehabilitation using protocols that had previously proven successful in adults. The patient trained at home and in the laboratory, on a psychophysical task that required discrimination of complex motion stimuli presented in the blind field. Visual function was assessed before and after training, using perimetric measures, as well as a battery of psychophysical tests.
RESULTS: The patient showed remarkably rapid improvements on the training task, with performance going from chance to 80% correct over the span of 11 sessions. With further training, improved vision was found for untrained stimuli and for perimetric measures of visual sensitivity. Some, but not all, of these performance gains were retained upon retesting after one year.
CONCLUSIONS: These results suggest that existing vision rehabilitation programs can be highly effective in adult patients who acquired CVI at a young age. Validation with a large sample size is critical, and future work should also focus on improving the usability and accessibility of these programs for younger patients.