背景:评估MP-3微周边生物反馈固定训练(MBFT)在患有中心性视力丧失的黄斑疾病的低视力患者的视力康复中的疗效。
方法:17只眼(7例年龄相关性黄斑变性,17例患者中的10例近视性黄斑病变)被纳入本前瞻性研究,介入研究。通过全面的眼底镜检查包括眼底照相来确定首选的视网膜位置,自发荧光,光学相干层析成像,和显微视野。康复包括每只眼睛进行三次10分钟的疗程,每周两次,连续20周,使用MP-3微周长。最佳矫正视力(BCVA),阅读速度,平均中央灵敏度,指定区域内固定点的百分比,在训练前后记录双变量轮廓椭圆面积(BCEA)和25项国家眼科研究所视觉功能问卷(NEI-VFQ-25)。
结果:最终的BCVA,康复后阅读速度和平均中枢敏感度均有显著改善(分别为P<0.0001,P=0.0013和P=0.0002).训练后,位于2°和4°直径圆圈内的固定点百分比均显着增加(分别为P=0.0008和P=0.0007)。包含68.2、95.4、99.6%的固定点的BCEA在训练后均显着降低(分别为P=0.0038,P=0.0022和P=0.0021)。康复训练结束时NEI-VFQ-25评分明显升高(P<0.0001)。
结论:使用MP-3MBFT进行康复治疗是改善视觉功能的一种用户友好的治疗选择,固定稳定性,和晚期黄斑疾病的生活质量。
背景:前瞻性研究已在中国临床试验注册中心注册(http://www.chictr.org.cn/)。
背景:ChiCTR2000029586。注册日期:05/02/2020。
BACKGROUND: To evaluate the efficacy of MP-3 microperimeter biofeedback fixation training (MBFT) in vision rehabilitation of low-vision patients affected by macular disease with central vision loss.
METHODS: Seventeen eyes (7 age-related macular degeneration, 10 myopic maculopathy) of 17 patients were included in this prospective, interventional study. The preferred retinal locus was determined by comprehensive ophthalmoscopic fundus evaluation including fundus photography, autofluorescence, optical coherence tomography, and microperimetry. The rehabilitation consisted of three 10-min sessions per eye to be performed twice per week for 20 consecutive weeks using the MP-3 microperimeter. Best corrected visual acuity (BCVA), reading speed, mean central sensitivity, the percentages of fixation points within specified regions, bivariate contour ellipse area (BCEA) and the 25-item National Eye Institute visual function questionnaire (NEI-VFQ-25) were recorded pre- and post-training.
RESULTS: The final BCVA, reading speed and mean central sensitivity all showed significant improvements after rehabilitation (P < 0.0001, P = 0.0013, and P = 0.0002, respectively). The percentages of fixation points located within 2° and 4° diameter circles both significantly increased after training (P = 0.0008 and P = 0.0007, respectively). The BCEA encompassing 68.2, 95.4, 99.6% of fixation points were all significantly decreased after training (P = 0.0038, P = 0.0022, and P = 0.0021, respectively). The NEI-VFQ-25 scores were significantly increased at the end of the rehabilitation training (P < 0.0001).
CONCLUSIONS: Rehabilitation with MP-3 MBFT is a user-friendly therapeutic option for improving visual function, fixation stability, and quality of life in advanced macular disease.
BACKGROUND: The prospective study was registered with the Chinese Clinical Trial Registry ( http://www.chictr.org.cn/ ).
BACKGROUND: ChiCTR2000029586 . Date of registration: 05/02/2020.