pseudotumor

假瘤
  • 文章类型: Case Reports
    目的:血友病假瘤(HP)是一种非常罕见的血友病并发症,仅在1-2%的病例中可见。虽然它在长骨中更常见,骨盆和手脚的小骨头,很少涉及颌骨。
    结果:在本例中,存在罕见的下颌骨血友病假瘤,并有乙型血友病阳性病史,临床和放射学检查足以得出决定性的诊断,排除了侵入性诊断程序,例如活检,从而避免了出血的风险。感染,或瘘管。该病例还突出显示,患者单独使用因子IX替代保守管理,具有非常好的临床结果。
    结论:HP应被视为严重血友病患者中任何进行性硬组织和软组织肿胀的鉴别诊断。
    OBJECTIVE: Hemophilic pseudotumor (HP) is a very rare complication of hemophilia seen in only 1-2% of the cases. Although it is much more common in long bones, pelvis and small bones of hands and feet and very rarely involving jaw bones.
    RESULTS: In the present case, the presence of a rare hemophilic pseudotumor of the mandible with the positive history of Hemophilia B justifies that the history, clinical and radiological examinations were sufficient to arrive at conclusive diagnosis precluding invasive diagnostic procedures such as biopsy hence avoiding the risk of hemorrhage, infection, or fistula. This case also highlights that patient was conservatively managed with Factor IX replacement alone with a very good clinical outcome.
    CONCLUSIONS: HP should be considered as a differential diagnosis of any progressive swelling of hard and soft tissues occurring in a patient with severe haemophilia.
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  • 文章类型: Case Reports
    罕见且神秘的肺部炎性肌纤维母细胞瘤(PIMT)主要影响儿童和年轻人。PIMT的特征在于与炎性细胞混合的成肌纤维梭形细胞的增殖。它可以类似于良性和恶性疾病,影像学和临床。PIMT通常表现为孤立性肺肿瘤。肿瘤的发生与遗传异常有关,包括与ALK基因(间变性淋巴瘤激酶)相关的基因;尽管如此,有些病例不是ALK阳性,表明遗传变异性。临床上,患者可能有咳嗽等非特异性症状,胸痛,或者咯血,或者他们可能根本没有任何症状。在这些情况下,影像学检查可能无意中发现无关的情况.从组织病理学的角度来看,PIMT的特征是异质细胞组成,包括淋巴细胞,肌成纤维细胞,浆细胞,和组织细胞,通常表现出束状或柱状图案。通过免疫组织化学标记证实诊断,分子研究,和组织学检查。治疗的基石仍然是手术切除,预后良好,复发率低。另一方面,具体治疗,如ALK抑制剂,对无法治愈或反复出现的情况显示出希望。尽管PIMT通常有良性病史,了解其生物学行为和分子基础对于精确诊断和有效管理至关重要。这强调需要对PIMT的病理生理学和潜在治疗进行进一步研究。本报告介绍了一例53岁的女性,她抱怨呼吸困难和胸痛,并被意外诊断出患有这种疾病。
    The uncommon and mysterious pulmonary inflammatory myofibroblastic tumor (PIMT) primarily affects children and young people. PIMT is characterized by the proliferation of myofibroblastic spindle cells mixed with inflammatory cells. It can resemble both benign and malignant disorders, both radiographically and clinically. PIMT typically manifests as a solitary lung tumor. The genesis of the tumor is linked to genetic anomalies, including those related to the ALK gene (anaplastic lymphoma kinase); nonetheless, some cases are not ALK-positive, indicating genetic variability. Clinically, patients may have non-specific symptoms such as cough, chest pain, or hemoptysis, or they may not exhibit any symptoms at all. In these cases, imaging tests may unintentionally reveal unrelated conditions. From a histopathological perspective, PIMT is characterized by a heterogeneous cellular makeup, encompassing lymphocytes, myofibroblasts, plasma cells, and histiocytes, which generally exhibit a fascicular or storiform pattern. The diagnosis is verified using immunohistochemical labeling, molecular research, and histological examination. The cornerstone of treatment is still surgical resection, which has a good prognosis and a low recurrence rate. On the other hand, specific treatments, such as ALK inhibitors, have shown promise for incurable or recurring instances. Even though PIMT usually has a benign history, it is important to comprehend its biological behavior and molecular foundations for precise diagnosis and efficient management. This underscores the need for additional study into the pathophysiology and potential treatments of PIMT. This report presents a case of a 53-year-old female who presented with complaints of breathlessness and chest pain and was diagnosed with the condition accidentally.
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  • 文章类型: Case Reports
    脑膜炎是全球重大的健康问题,肠道病毒(EV)是成人病毒性脑膜炎的最常见原因。我们讨论了一名57岁的女性肠道病毒性脑膜炎患者,表现为假性脑瘤,带来了重大的临床挑战。她出现了症状,标志,和放射学证据表明特发性颅内高压。脑脊液分析显示细胞增多,这导致了进一步的研究,通过实时逆转录聚合酶链反应分析揭示了EV的阳性病例。此病例突出表明,并非所有颅内压升高的病例都是有害或顽固的。它强调了全面诊断评估的必要性,并强调了保守管理带来有利结果的潜力。
    Meningitis is a significant health concern globally, with enterovirus (EV) being the most common cause of viral meningitis in adults. We discuss the case of a 57-year-old female patient with enteroviral meningitis manifesting as pseudotumor cerebri, posing significant clinical challenges. She presented with symptoms, signs, and radiological evidence suggesting idiopathic intracranial hypertension. The CSF analysis showed pleocytosis, which led to further investigations that unveiled a positive case of EV by real-time reverse transcription polymerase chain reaction analysis. This case highlights the fact that not all cases of raised intracranial pressure are detrimental or recalcitrant. It accentuates the need for thorough diagnostic evaluation and emphasizes the potential for favorable outcomes with conservative management.
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  • 文章类型: Case Reports
    张量筋膜(TFL)肌肉的单侧肥大是一种罕见的疾病,通常以下肢明显的肿块或髋部疼痛为特征。尽管它很罕见,已经确定了几个致病因素,需要准确的诊断和适当的管理。这里,我们介绍了一例53岁的患者,该患者因右大腿前外侧肿块寻求门诊咨询.通过这个案例研究,我们的目标是通过讨论我们的诊断方法来为关于这种情况的有限文献做出贡献,管理计划,和结果。在介绍时,病人接受了彻底的体检,揭示了一个非招标,无柄肿块似乎起源于大腿的深层结缔组织。进行磁共振成像(MRI)以确认诊断并评估肌肉受累的程度。这种非侵入性的方式为肿块的性质和定位提供了有价值的见解,提供诊断并指导后续管理决策。鉴于病情的良性性质和没有相关症状,保守管理受到青睐。开始了以伸展和加强运动为重点的物理疗法,以解决潜在的可能原因并提高功能能力。还建议通过定期随访进行密切监测,以跟踪肥大的进展并确保症状缓解。TFL肌肉的单侧肥大是一种罕见的实体,存在诊断和管理挑战。通过我们的案例研究,我们强调了全面诊断检查的重要性,包括影像学研究,在确认诊断和指导管理决策方面。保守的方法,比如物理治疗,可以有效地管理症状并改善受影响个体的生活质量。继续研究和记录病例对于扩大我们对这种情况的理解和完善治疗策略至关重要。
    Unilateral hypertrophy of the Tensor Fasciae Latae (TFL) muscle is a rare condition often characterized by a palpable mass in the lower limbs or hip pain. Despite its rarity, several causative factors have been identified, necessitating accurate diagnosis and appropriate management. Here, we present the case of a 53-year-old patient who sought outpatient consultation for a mass in the anterolateral aspect of the right thigh. Through this case study, we aim to contribute to the limited literature on this condition by discussing our diagnostic approach, management plan, and outcomes. Upon presentation, the patient underwent a thorough physical examination, revealing a non-tender, sessile mass seemingly originating in the deep connective tissue of the thigh. A magnetic resonance image (MRI) was performed to confirm the diagnosis and assess the extent of muscle involvement. This noninvasive modality provided valuable insights into the nature and localization of the mass, providing the diagnosis and guiding subsequent management decisions. Given the benign nature of the condition and absence of associated symptoms, conservative management was favored. Physical therapy focusing on stretching and strengthening exercises was initiated to address the underlying probable causes and improve functional capacity. Close monitoring through regular follow-up appointments was also recommended to track the progression of the hypertrophy and ensure symptomatic relief. Unilateral hypertrophy of the TFL muscle is a rare entity that presents diagnostic and management challenges. Through our case study, we have highlighted the importance of a comprehensive diagnostic workup, including imaging studies, in confirming the diagnosis and guiding management decisions. Conservative approaches, such as physical therapy, can effectively manage symptoms and improve quality of life in affected individuals. Continued research and documentation of cases are essential to expand our understanding of this condition and refine treatment strategies.
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  • 文章类型: Journal Article
    全髋关节置换术(THA)是治疗晚期髋关节退变的最佳手术方法,提供疼痛缓解,和改善功能在大多数情况下。在过去,MR成像质量受到平面内畸变的严重影响,脂肪饱和度不足,和其他由THA的金属成分引起的伪影。技术进步使病理状况,以前被假体周围的人工制品隐藏起来,由于几个序列的优化,突出的功能。迄今为止,通过磁共振成像(MRI)可以检测到一些涉及骨和软组织结构的短期和长期并发症.使用具有适应的序列和协议的MRI可以大大减少伪影,从而为计划失败的THA的翻修手术提供必要的术前要素。这篇评论的目的是向肌肉骨骼放射科医生传达有关抑制金属相关伪影的技术以及疼痛性THA的标志性MRI发现的新见解。关键相关性声明:金属抑制技术的进步使放射科医师有机会在THA管理中发挥新的作用。本文提供了有关THA案例中可能遇到的挑战的技术和成像见解,可能会出现并发症和特征性影像学表现。要点:成像全髋关节置换术需要适应的MRI方案和常见并发症的认识。我们已经报道了评估全髋关节置换术的可用金属抑制序列。在处理疼痛性无菌或脓毒性关节成形术时,应考虑许多结构和条件。
    Total hip arthroplasty (THA) is the best surgical approach for treating advanced hip degeneration, providing pain relief, and improved function in most cases. In the past, MR imaging quality has been highly compromised by in-plane distortions, inadequate fat saturation, and other artifacts due to metal components of THA. Technological advancements have made pathologic conditions, which were previously hidden by periprosthetic artifacts, outstanding features due to the optimization of several sequences. To date, several short and long-term complications involving bony and soft-tissue structures may be detected through magnetic resonance imaging (MRI). The use of MRI with adapted sequences and protocols may drastically reduce artifacts thereby providing essential pre-operative elements for planning revision surgery of failed THA. This review has the purpose of conveying new insights to musculoskeletal radiologists about the techniques to suppress metal-related artifacts and the hallmark MRI findings of painful THA. CRITICAL RELEVANCE STATEMENT: Advancements in metal-suppression have given radiologists the opportunity to play an emerging role in THA management. This article provides technical and imaging insights into challenges that can be encountered in cases of THA, which may present complications and characteristic imaging findings. KEY POINTS: Imaging total hip arthroplasty requires adapted MRI protocol and awareness of the common complications. We have reported the available metal-suppression sequences for evaluating total hip arthroplasty. Many structures and conditions should be considered when dealing with painful aseptic or septic arthroplasty.
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  • 文章类型: Case Reports
    肺部的炎性肌纤维母细胞瘤(IMT)是一种罕见的间充质肿瘤,倾向于在儿童肺部发生更多。在成年人中极为罕见。IMT需要广泛的肺切除术,因为它们通常是局部侵入性的。防止复发的关键是完全切除,手术后预后良好。我们报告了一例肺部炎性假瘤患者。患者是一名27岁的女性,出现干咳。胸部X光片和计算机断层扫描显示左主支气管有病变,左肺几乎完全塌陷。因为手术是必要的,以确定诊断,进行左肺切除术,然后对手术标本进行组织学检查,证实是炎性假瘤.
    Inflammatory myofibroblastic tumors (IMTs) of the lung are a rare type of mesenchymal tumors that tend to occur more in the lungs of children. They are extremely rare in adults. IMTs require extensive pulmonary resection because they are commonly locally invasive. The key to preventing recurrence is complete resection, and the prognosis is excellent after surgery. We report a case of a patient with an inflammatory pseudotumor of the lung. The patient is a 27-year-old female who presented with a dry cough. A chest radiograph and computed tomography showed a lesion in the left main bronchus and near-total left lung collapse. As surgery was necessary to establish the diagnosis, left pneumonectomy was performed followed by a histological examination of the surgical specimen which confirmed inflammatory pseudotumor.
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  • 文章类型: Journal Article
    结肠纤维瘤病(FC)是一种罕见的胸锁乳突肌假瘤,发生率为0.4%,通常在2至4周龄之间使用超声诊断。考虑到由于其表现为伴有斜颈的宫颈肿块而引起的临床关注,这是一个重要的实体。很少对其外观进行磁共振成像(MRI)描述,现有报告的病例是零星的。我们的目标是提供这个儿科实体的全面描述。
    我们进行了一项回顾性研究,在我们医院的数据库中搜索了以前进行过MRI的FC病例。我们发现了6例进行了MRI的FC。在这些案件中,六分之五是对比增强的。我们检查了MRI,以能够辨别和描述FC的MRI特征。
    我们发现FC向肌肉呈现T1信号等强度,对肌肉的T2信号强度过高,在对比剂给药后,可变的扩散信号和厚的增强外周环。
    我们的结果与迄今为止文献中关于FC的MRI信号的报道相符,确认以前的报告。然而,我们提供了有关增强后特征外观的新数据,这是以前没有报道的。
    FC的MRI特征很少被描述,医学文献中只有少数孤立的病例报告。我们回顾了当前的文献,描述病理学的关键MRI特征,并提供迄今为止最彻底的描述。
    UNASSIGNED: Fibromatosis colli (FC) is a rare pseudotumor of the sternocleidomastoid muscle with an incidence of 0.4%, generally diagnosed using ultrasound between 2 and 4 weeks of age. This is an important entity considering the clinical concerns it causes due to its appearance as a cervical mass with torticollis. Few magnetic resonance imaging (MRI) descriptions of its appearance have been made, with the existing reported cases being sporadic. We aim to provide a thorough description of this paediatric entity.
    UNASSIGNED: We conducted a retrospective study by searching our hospital\'s database for previous cases of FC where an MRI had been performed. We found six cases of FC where an MRI had been performed. Of these cases, five out of six were contrast-enhanced. We examined the MRIs to be able to discern and describe the MRI characteristics of FC.
    UNASSIGNED: We found that FC presents a T1 signal isointense to the muscle, a T2 signal hyperintense to the muscle, a variable diffusion signal and a thick enhancing peripheral ring after contrast administration.
    UNASSIGNED: Our results match what has been reported in the literature to date regarding the MRI signal of FC, confirming previous reports. However, we provide new data regarding the characteristic appearance post-enhancement, which was previously unreported.
    UNASSIGNED: The MRI characteristics of FC have rarely been described, with only a few isolated case reports in the medical literature. We review the current literature, describe the key MRI characteristics of the pathology, and provide the most thorough description to date.
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  • 文章类型: Case Reports
    IgG4相关疾病是一种罕见且新兴的病理,以伪肿瘤的出现为特征。由于模仿其他病理的能力,将其视为多系统过程的鉴别诊断至关重要。诊断很有挑战性,需要多学科的方法,尽量减少相关的发病率和死亡率。
    IgG4相关疾病(IgG4-RD)是一种罕见的疾病,新兴,系统和慢性病理学,其特征是由于IgG4阳性浆细胞的组织浸润而出现假瘤,从而促进组织的嗜酸性粒细胞炎症并随后纤维化。我们介绍一个男性的案例,45岁的病人,他的家庭医生在女儿的儿童健康咨询中发现了明显的体重减轻和皮肤苍白。当被质疑时,患者以饱胀的感觉转述了左软骨下餐后不适的抱怨,减肥,持续一个月的慢性疲劳和多汗症。在体检时,他脸色苍白,触诊左侧软骨下有疼痛。实验室数据显示炎症标志物增加,腹部超声和CT显示上象限有许多肿大的淋巴结,引起对恶性淋巴增生过程的关注。血清学,成像,临床和腹腔镜切除活检显示IgG4相关疾病的特征,并排除恶性淋巴增生性疾病.对口服泼尼松龙30mg/天治疗的即时反应也有助于诊断确认。由于难治性疾病后逐渐减少泼尼松龙,利妥昔单抗的二线治疗开始.在6年的随访中,患者出现了以出现全身症状为特征的多次加重,通过病理学保持密切的临床和影像学随访,传染病,和家庭医学专家。
    UNASSIGNED: IgG4-related disease is a rare and emerging pathology, characterized by the appearance of pseudotumors. Due to the ability to mimic other pathologies, it is essential to consider it as a differential diagnosis in multisystemic processes. The diagnosis is challenging, requiring a multidisciplinary approach, to minimize the associated morbidity and mortality.
    UNASSIGNED: IgG4-related disease (IgG4-RD) is a rare, emerging, systemic and chronic pathology, characterized by the appearance of pseudotumors resulting from tissue infiltration by IgG4-positive plasma cells that promote eosinophilic inflammation of the tissue with subsequent fibrosis. We present the case of a male, 45-year-old patient, with marked weight loss and skin pallor detected by his family doctor during a child health consultation of his daughter. When questioned, the patient referred complaints of postprandial discomfort in the left hypochondrium with a feeling of fullness, weight loss, chronic fatigue and hyperhidrosis that had lasted for a month. On physical examination, he was pale, and had pain at palpation of the left hypochondrium. Laboratory data showed increased inflammation markers, abdominal ultrasound and CT demonstrated numerous enlarged lymph nodes in the upper quadrants, raising concern for a malignant lymphoproliferative process. Serological, imaging, clinical and laparoscopic excisional biopsy revealed features of IgG4-related disease and excluded malignant lymphoproliferative disease. The immediate response to treatment with oral prednisolone 30 mg/day also contributed for diagnosis confirmation. Due to refractory disease after gradual prednisolone reduction, second-line therapy with rituximab was initiated. Over the 6 years of follow-up, the patient presented multiple exacerbations characterized by the emergence of systemic symptoms, being maintained under close clinical and imaging follow-up by reumathology, infectious diseases, and family medicine specialists.
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  • 文章类型: Journal Article
    目的:炎性肌纤维母细胞瘤(IMT)是罕见的,固体,病因不明的潜在恶性病变。组织学上,IMT在成纤维细胞粘液样层内表现出淋巴细胞和炎性细胞的组合。IMT的诊断对各种医学专业提出了挑战,包括外科医生,病理学家,和肿瘤学家,由于他们的非特异性临床表现。此外,放射科医生在解释计算机断层扫描(CT)或磁共振成像(MRI)结果方面面临困难,通常会产生多态性和不确定的发现。最终,组织病理学家在根据肿瘤的组织学特征做出明确诊断方面起着至关重要的作用。它们在人体的每个系统中都被检测到,最常见的是肺部。这里,我们报道了1例非特异性腹痛患者脾脏IMT的罕见发生.
    方法:一名56岁的白种人女性被送到NeaIonia的Konstantopouleio总医院,雅典,希腊,腹痛和不适。患者没有明显的病史和正常的实验室检查。腹部CT显示脾脏有大量肿块。进行了脾切除术。肿瘤的组织病理学分析显示IMTS。
    结论:脾IMT是一种具有中度恶性潜能的罕见良性肿瘤。它缺乏独特的临床表现,通常是偶然或在腹痛检查期间发现的。
    OBJECTIVE: Inflammatory myofibroblastic tumors (IMTs) are rare, solid, potentially malignant lesions of uncertain etiology. Histologically, IMTs exhibit a combination of lymphocytes and inflammatory cells within a fibroblastic myxoid layer. The diagnosis of IMTs poses a challenge for various medical specialties, including surgeons, pathologists, and oncologists, due to their non-specific clinical presentation. Furthermore, radiologists face difficulties in interpreting computed tomography (CT) or magnetic resonance imaging (MRI) results, which often yield polymorphic and inconclusive findings. Ultimately, histopathologists play a crucial role in reaching a definitive diagnosis based on the tumor\'s histological characteristics. They are detected in every system of the human body, most commonly in the lungs. Here, we report an uncommon occurrence of IMT in the spleen of a patient with nonspecific abdominal pain.
    METHODS: A 56-year-old Caucasian female presented to Konstantopouleio General Hospital of Nea Ionia, Athens, Greece, with abdominal pain and discomfort. The patient had no significant medical history and normal laboratory tests. An abdominal CT revealed a large mass in the spleen. A splenectomy was performed. Histopathological analysis of the tumor revealed IMTS.
    CONCLUSIONS: Splenic IMT is a rare benign tumor with moderate malignant potential. It lacks a distinct clinical presentation and is typically identified either incidentally or during the examination of abdominal pain.
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  • 文章类型: Case Reports
    结核病构成了重大的公共卫生挑战,特别是在高度流行的国家。很少,它看起来像一个类似于恶性腹部肿瘤的腹部肿块,在成像上可能会产生误导,所以早期诊断仍然是一个挑战,和确认可能需要侵入性检查,如剖腹手术。最具特征的放射学外观是固体,高血管,或外周增强的肿块,中心密度低。我们介绍了一例腹膜后结核,在影像学上模拟了畸胎瘤。这种情况突出了即使在流行国家的诊断困难,尽管超声和计算机断层扫描等成像技术取得了进展。
    Tuberculosis poses a significant public health challenge, especially in highly endemic countries. Rarely, it appears as an abdominal mass resembling a malignant abdominal tumor and can be misleading on imaging, so early diagnosis remains a challenge, and confirmation may require invasive examinations such as laparotomy. The most characteristic radiological appearance is that of a solid, hypervascular, or peripherally enhancing mass with a hypodense center. We present a case of retroperitoneal tuberculosis that simulated a teratoma on imaging. This case highlights the diagnosis difficulties even in endemic countries, despite advances in imaging techniques such as ultrasound and computed tomography.
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